Publications by authors named "Matilde Santos-Roncero"
Article Synopsis
- BCR-JAK2 is a rare gene fusion linked to various types of leukemia that do not involve the Philadelphia chromosome; this study shows that its expression in mice causes severe cancer development.
- Transplanting bone marrow with BCR-JAK2 leads to enlarged spleens, excessive white blood cells, and the presence of immature myeloid cells in the blood, indicating serious blood-related issues.
- The findings suggest that BCR-JAK2 promotes leukemia by disrupting normal cell death processes, which may help in creating new targeted treatments for Philadelphia chromosome-negative leukemia.
Chromosomal translocations in tumors frequently produce fusion genes coding for chimeric proteins with a key role in oncogenesis. Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of the chimeric protein remains uncharacterized. We used fluorescence in situ hybridization and reverse transcription polymerase chain reaction (RT-PCR) assays to describe a BCR-JAK2 fusion gene from a patient with acute lymphoblastic leukemia.
View Article and Find Full Text PDFPurpose: The role of molecular monitoring of minimal residual disease (MRD) in low-grade non-Hodgkin's lymphoma is controversial. We have performed a prospective study of the molecular behavior of 35 patients with follicular non-Hodgkin's lymphoma who received cyclophosphamide-vincristine-prednisone chemotherapy in conjunction with IFN-alpha 2b.
Experimental Design: Bcl-2 and clonal immunoglobulin heavy chain (IgH) gene rearrangements were assayed at diagnosis by PCR in lymph node and bone marrow (BM) and sequentially after treatment.