Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation.

Manipulation of adrenergic signaling has been shown experimentally and clinically to affect hair follicle growth. In this study, we provide direct evidence that canonical cAMP/CRE-binding protein signaling through adrenergic receptors can regulate hair follicle stem cell (HFSC) activation and hair cycle. We found that CRE-binding protein activation is regulated through the hair cycle and coincides with HFSC activation.

Hip to the Game: YAP/TAZ is required for nonmelanoma skin cancers.

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the two most common skin cancers found in humans. These cancers can acquire drug resistance and pose considerable medical burdens to clinics and patients if left untreated. Two recent studies show that active Hippo signaling plays a critical role in initiating BCC and SCC tumorigenesis, providing new opportunities to develop therapies against these skin malignancies.

Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle.

While many signaling pathways have been implicated in control of activation of adult hair follicle stem cells and the hair cycle, less is known about cell intrinsic mechanisms of stem cell control. We previously identified lactate production as a key cell intrinsic regulator of hair follicle stem cell activity, suggesting that cellular metabolism is important in stem cell activation. Others have used transgenic methods to suggest that transgenic blockade of the Electron Transport Chain (ETC) leads to degeneration of the hair follicle.

Lactate dehydrogenase activity drives hair follicle stem cell activation.

Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis.

[Social relations between the nursing team and the parents of hospitalized children].

By means of partially structured interviews and assistematic observation, the authors attempt to identify the types of social relations that occur between the nursing team and the parents visiting the hospitalized child.

[Popular use of medicinal plants in infancy: implications for nursing].

An exploratory study is made by nurses -with a group of mothers with the purpose of identifying reasons for the popular use of medicinal plants by mothers caring for their children within the 0-2 years age range. Influence of the social, economical and cultural factores involved are considered. The implications of this data for nursing care and for teaching it are described.

[Student-centered teaching: an experience told by nursing studentes being taught under this method].

Four master's degree nursing students tell of their learning experience in a pediatric nursing program based on student-centered teaching methodology. The students relate their initial doubts about the effectivity of the methodology, the difficulties they encountered in formulating a program to be followed, and their observations of the behavior and the attitudes presented by their teacher-facilitator. In order to attain their particular learning objectives for the program, the group chose to start an experiment involving maternal-child care in a slum area of são Paulo.

[Research in maternal-child nursing].

By way of a short bibliographical revision, these authors outline some general directives for research in the maternal-child area of nursing. They identify existing research projects in this area, which are published in three bibliographical sources. They depict the predominance of emphasis in these projects - be it nursing assistance, administration or teaching.