Publications by authors named "Matilda Wallenberg"
Pharmacogenomics
October 2022
Article Synopsis
- A genome-wide association study (GWAS) was conducted on 346 rheumatoid arthritis (RA) patients starting low-dose methotrexate (MTX) to find genetic variants linked to increased levels of alanine aminotransferase (ALT).
- The study focused on two specific outcomes within the first six months of MTX treatment: ALT levels exceeding 1.5 times the normal upper limit and the maximum observed ALT levels.
- Significant associations were found for the variants rs72783407 (linked to maximum ALT levels) and rs60427389 (tentatively linked to ALT levels >1.5 × ULN), including links to genes related to male fertility and inflammation.
Pharmacogenomics
October 2021
Article Synopsis
- * Conducted genome-wide association studies with 198 RA patients, focusing on maximum ALT levels and ALT levels exceeding 1.5 times the normal range within the first 6 months of MTX.
- * Found significant associations between ALT elevation and specific genetic variants, including rs72675408, which may influence gene expression related to rheumatoid arthritis pathogenesis.
