Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.

The putative involvement of chromatin states in multiple sclerosis (MS) is thus far unclear. Here we determined the association of chromatin-accessibility with concurrent genetic, epigenetic and transcriptional events. We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4 and CD8 T cells, CD14 monocytes and CD19 B cells from healthy controls (HCs) and MS patients.