Lack of correlation between central venous minus arterial PCO to arterial minus central venous O content ratio and respiratory quotient in patients with septic shock: A prospective observational study.

Objective: Central venous-arterial PCO to arterial-central venous O content ratio (PCO/CO) is commonly used as a surrogate for respiratory quotient (RQ) and tissue oxygenation. Although PCO/CO might be associated with hyperlactatemia and outcome, neither the interchangeability with RQ nor the correlation with conclusive variables of anaerobic metabolism has never been demonstrated in septic shock. Our goal was to compare PCO/CO and RQ in patients with septic shock.

The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies.

The key objective in the hemodynamic treatment of septic shock is the optimization of tissue perfusion and oxygenation. This is usually achieved by the utilization of fluids, vasopressors, and inotropes. Dobutamine is the inotrope most commonly recommended and used for this purpose.