Publications by authors named "Matias Elliott"
Background: Angiogenesis, the process in which new blood vessels are formed from preexisting ones, is highly dependent on the presence of classical angiogenic factors. Recent evidence suggests that axonal guidance proteins and their receptors can also act as angiogenic regulators. Netrin, a family of laminin-like proteins, specifically Netrin-1 and 4, act via DCC/Neogenin-1 and UNC5 class of receptors to promote or inhibit angiogenesis, depending on the physiological context.
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- Disorders in skin wound healing are prevalent and need new treatment options; biomaterials have potential but face challenges like poor vascularization.
- A study developed collagen-based scaffolds with mesenchymal stem cells from Wharton's jelly (WJ-MSC) to enhance healing in a mouse model.
- WJ-MSCs showed higher growth factor secretion linked to angiogenesis and improved healing response without affecting inflammation, making them a promising option for tissue engineering.