Publications by authors named "Matias E Fusini"
Metronomic chemotherapy (MCT) is a cancer therapeutic approach characterized by low dose drug chronic administration and limited or null toxicity. Obesity-induced metabolic alterations worsen cancer prognosis and influence the intestinal biochemical barrier, altering the Multidrug resistance-associated protein 2 (Mrp2) and Multidrug resistance protein-1 (Mdr-1), efflux pumps that transport chemotherapeutic drugs. Obesity and cancer are frequent co-morbidities; thus, our aim was to evaluate the effectiveness and toxicity of MCT with cyclophosphamide (Cy) in obese mice with metabolic alterations bearing a mammary adenocarcinoma.
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- This study looked at how a protein called COX-2 affects liver damage caused by a condition called cholestasis, where bile can't flow properly.
- Scientists used specially modified mice that always express COX-2 in their liver cells to see if it helps protect against liver injury.
- The results showed that these COX-2 mice had less liver damage and inflammation, improved bile acid processing, and were better at handling stress in the liver compared to regular mice.