Publications by authors named "Mathis Ratel"
Microbiol Spectr
April 2022
Article Synopsis
- HPV circulating tumor DNA (ctDNA) is proposed as a biomarker for detecting and monitoring HPV-related cancers, specifically focusing on cervical cancer caused by HPV16.
- A study analyzed 180 plasma samples from women with HPV16-positive cervical cancer, premalignant lesions, and HPV DNA-negative controls, evaluating the effectiveness of a new bead-based genotyping assay (E7-MPG) compared to droplet digital PCR (ddPCR) and E6 antibody detection.
- The E7-MPG detected HPV16 ctDNA in 42.3% of all samples and 74.7% of cervical cancer cases, proving more sensitive than ddPCR and showing that combining it with E6 antibodies further increased detection sensitivity to 86
