Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation.

Background: Trisomy 21 (T21) is associated with intellectual disability that ranges from mild to profound with an average intellectual quotient of around 50. Furthermore, T21 patients have a high risk of developing Alzheimer's disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. We postulate that epigenetic factors contribute to the observed variability in intellectual disability, as well as at the level of neurodegeneration seen in T21 individuals.

Protective Actions of Oral Administration of CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model.

Objective: The aim of this study was to evaluate the effects of a lyophilized inactivated culture (LIC) from CBi0703 in a spontaneous model of osteoarthritis (OA) in Dunkin Hartley guinea pigs. Histology of cartilage and synovial membrane was the primary outcome. Biomarkers were also considered to evaluate the treatment efficacy.