Publications by authors named "Mathilde Robin"
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) shows treatment resistance due to a dense stroma and immunosuppressive microenvironment, prompting research into combining FOLFIRINOX chemotherapy with VE-822, a DNA repair inhibitor.* -
- The study utilized PDAC spheroid models and mouse models to analyze the combination's effects on tumor growth and the immune and fibrotic environment, revealing a strong synergistic effect and increased apoptosis.* -
- Results indicated that the FOLFIRINOX and VE-822 combo significantly inhibited tumor growth more than FOLFIRINOX alone, improved immune cell activity, and modified the tumor microenvironment, suggesting a potential strategy to enhance treatment effectiveness.*
YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies. In fewer cases, they have also been shown to oppose cancer progression, including by promoting cell death through the action of the p73/YAP transcriptional complex, in particular after chemotherapeutic drug exposure.
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