Publications by authors named "Mathilde Pucher"
Article Synopsis
- Arylborinic acids are a newly discovered type of compound that can effectively respond to hydrogen peroxide, with potential applications in drug delivery and fluorescent imaging.!
- Unlike traditional boronic acids, arylborinic acids undergo two oxidative rearrangements during their oxidation process, which could limit how efficiently they release their therapeutic or fluorescent components.!
- A study identified the o-CF substituent as a key component that enhances selective oxidation, leading to the development of new fluorescent probes that only activate in the presence of hydrogen peroxide, showcasing better performance than their boronic acid counterparts.!
Evaluation of borinic acids as new, fast hydrogen peroxide-responsive triggers.
Proc Natl Acad Sci U S A
December 2021
Hydrogen peroxide (HO) is responsible for numerous damages when overproduced, and its detection is crucial for a better understanding of HO-mediated signaling in physiological and pathological processes. For this purpose, various "off-on" small fluorescent probes relying on a boronate trigger have been prepared, and this design has also been involved in the development of HO-activated prodrugs or theranostic tools. However, this design suffers from slow kinetics, preventing activation by HO with a short response time.
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