Publications by authors named "Mathilde Meot"
The patent ductus arteriosus is a very common condition in preterm infants, and a hemodynamically significant patent ductus arteriosus increases morbidity and mortality in these vulnerable patients. However, despite numerous randomized controlled trials, there is no consensus regarding management. Medical therapy is typically offered as first-line treatment, although it yields limited success and carries the potential for severe adverse events.
View Article and Find Full Text PDFBackground: The primary genetic risk factor for heritable pulmonary arterial hypertension is the presence of monoallelic mutations in the gene. The incomplete penetrance of mutations implies that additional triggers are necessary for pulmonary arterial hypertension occurrence. Pulmonary artery stenosis directly raises pulmonary artery pressure, and the redirection of blood flow to unobstructed arteries leads to endothelial dysfunction and vascular remodeling.
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- The study compares the effects of using angiography contrast agents during transcatheter closure of patent ductus arteriosus (TCPDA) on kidney function in very low birth weight (VLBW) preterm infants.
- Results showed that serum creatinine levels significantly increased in infants treated with contrast agents compared to those who were not, indicating potential harm to renal function.
- The conclusion emphasizes the need to minimize or avoid the use of contrast agents during TCPDA to protect the kidney health of these vulnerable infants.
Background: A pulmonary sequestration (PS) is an area of bronchopulmonary tissue with aberrant arterial supply. Transcatheter occlusion of PSs is an appealing treatment option, but data on outcomes remain scarce. We aim to describe our experience with transcatheter management of PS in infants and children.
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- Right heart catheterization (RHC) is a high-risk procedure for children with pulmonary arterial hypertension, and this study aims to clarify its purpose and assess how well noninvasive indicators align with hemodynamic outcomes.
- The study analyzed data from 71 untreated children with pulmonary arterial hypertension, identifying specific hemodynamic metrics, like pulmonary vascular resistance index and right atrial pressure, that were associated with negative outcomes such as death and transplantation.
- While noninvasive criteria can suggest changes in hemodynamics, about 70% of children who showed improvement still had risk factors when reassessed with RHC, underscoring the importance of repeat procedures for ongoing risk evaluation.
Article Synopsis
- A newborn girl was suspected to have an abnormality in her pulmonary venous return, leading to an echocardiogram.
- The echocardiogram showed a significant outpouching from the left ventricle, which formed an accessory cardiac chamber connected to both the left ventricle and the right atrium through the coronary sinus.
- After ten years, a procedure was performed to close the opening between the submitral aneurysm and the left ventricle through a minimally invasive technique.
Article Synopsis
- Transcatheter closure of the patent arterial duct (TCPDA) is a new procedure for preterm infants, but the reasons and outcomes of failed attempts at this procedure are not well understood.* -
- A study reviewed data from premature infants who had discontinued TCPDA procedures, revealing that out of 130 patients, 14 experienced procedure failures due to factors like duct size and vessel obstruction.* -
- The results showed that in cases where TCPDA failed, 7 out of 12 patients achieved spontaneous closure of the patent arterial duct within a few days, suggesting that surgical intervention may not be immediately necessary.*
Patent ductus arteriosus (PDA) is common in preterm infants and contributes to morbidity and mortality. Several studies have shown the feasibility and safety of percutaneous PDA closure. Minimally invasive surgical ligation by anterior thoracotomy is an alternative, bedside technique for PDA closure in very low birth weight preterm infants.
View Article and Find Full Text PDFBackground: Prestenting right ventricular outflow tracts (RVOTs) before transcatheter pulmonary valve replacement (TPVR) is essential. Optimus-XXL (AndraTec GmbH, Koblenz, Germany) is a new extra-large, balloon-expandable cobalt-chrome stent with promising technologies.
Methods: From June 2020 to November 2020, 15 patients with congenital heart disease, dysfunctional RVOTs and target TPVR diameter ≥ 23 mm received Optimus-XXL stents before proceeding to TPVR using the SAPIEN valve (Edwards Lifesciences, Irvine, CA).
Background: Transcatheter patent arterial duct (PAD) closure in premature infants has been shown to be feasible. Since our early transcatheter PAD closure procedures in premature infants at Hôpital Necker Enfants Malades, we have changed our technique several times to advance the guidewire through the right heart to avoid tricuspid valve damage.
Aim: To describe the technique we have been using since May 2019, to report our results with a particular focus on tricuspid leaks and to analyse the potential mechanisms of tricuspid lesion development with previous methods.
Article Synopsis
- Sleep disordered breathing (SDB) is less common in children with chronic heart failure (CHF) compared to adults, but the effects of treatment like CPAP on their health are still being explored.
- In a study involving 30 children with CHF, most showed normal sleep efficiency and low rates of severe SDB, with only minor cases of obstructive symptoms.
- Using CPAP effectively reduced the work of breathing and respiratory rate in kids receiving treatment, without harming their cardiac function.
Article Synopsis
- The study evaluates the safety and effectiveness of the Amplatzer™ Trevisio™ intravascular delivery system (ATIDS) for closing atrial septal defects (ASDs) in children, as there are currently no published reports on its clinical use.
- Nine children with complex ASDs underwent successful closure procedures using ATIDS, with interventions guided by trans-esophageal echocardiography and fluoroscopy, all performed under general anesthesia.
- The results showed no serious complications or device issues, confirming complete closure of the shunt, and highlighted the system's precision and advantages in challenging anatomical conditions.
Article Synopsis
- Some kids with COVID-19 can get really sick and have heart problems, even if it's usually mild in children.
- A study looked at 35 kids who had serious heart issues and high inflammation during the pandemic.
- Luckily, most of the kids got better, and no one died, showing that doctors can help them recover from these heart problems.
Risk factors of mortality and recoarctation after coarctation repair in infancy.
Interact Cardiovasc Thorac Surg
September 2019
Article Synopsis
- The study investigates the long-term outcomes of aortic coarctation (CoA) repair in infants, focusing on predictors for future reintervention on the aortic arch.
- It included 530 infants treated before 3 months of age, with a follow-up median of 7.57 years, finding that 11.5% required further intervention.
- Key risk factors identified for reintervention included younger age at repair (less than 15 days) and the use of prostaglandin E1 (PGE1) during surgery, suggesting the need for more targeted research on PGE1's effects.
Double orifice and atrioventricular septal defect: dealing with the zone of apposition†.
Eur J Cardiothorac Surg
September 2019
Objectives: A double orifice of the left atrioventricular valve (LAVV) associated with atrioventricular septal defects (AVSD) can significantly complicate surgical repair. This study reports our experience of AVSD repair over 3 decades, with special attention to the zone of apposition (ZoA) of the main orifice, and presents a technique of hemivalve pericardial extension in specific situations.
Methods: We performed a retrospective study from 1987 to 2016 on 1067 patients with AVSD of whom 43 (4%) had a double orifice, plus 2 additional patients who required LAVV pericardial enlargement.
Article Synopsis
- Incontinentia pigmenti (IP) is a complex disorder linked to severe pulmonary arterial hypertension (PAH) that has a poor prognosis in previously reported cases.
- An infant diagnosed with IP exhibited severe health issues during a routine procedure, leading to the discovery of non-responsive precapillary PAH confirmed by right heart catheterization.
- The patient responded well to an aggressive treatment plan, including a combination of medications and anti-inflammatory therapies, resulting in normalization of pulmonary artery pressure after six months and cessation of all PAH treatments after 18 months.
Article Synopsis
- A study found that patients with tetralogy of Fallot (ToF), both with and without pulmonary atresia, showed a higher rate of tracheobronchial branching abnormalities (TBAs) compared to a control group.
- The researchers analyzed CT scans from 55 ToF patients without pulmonary atresia, 34 with pulmonary atresia, and 100 controls, observing that TBAs were significantly more common in ToF cases.
- The findings suggest a potential link between heart and airway abnormalities, offering new insights into the underlying mechanisms of certain congenital heart diseases.
Background: Branch pulmonary artery (BPA) stenosis is frequently associated with congenital heart disease. Management of BPA stenosis is challenging for surgeons due to a high rate of recurrence. The purpose of this study was to assess the results of intraoperative pulmonary artery stenting associated with or without surgical angioplasty.
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