Publications by authors named "Mathilde Maire"
Background: The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and transcriptomic pseudocapsules of 20 prospective sarcomas were analyzed and revealed to be correlated with a higher risk of recurrence after surgery.
Conclusions: A peritumoral environment that has been remodeled and infiltrated by M2 macrophages, and is less expressive of healthy tissue, would pose a significant risk of relapse and require more aggressive treatment strategies.
Introduction: Lymph node metastasis is determinant in the prognosis and treatment of endometrioid endometrial cancer (EEC) but the risk-benefit balance of surgical lymph node staging remains controversial.
Objective: Describe the pathways associated with lymph node metastases in EEC detected by whole RNA sequencing.
Methods: RNA-sequencing was performed on a retrospective series of 30 non-metastatic EEC.
Article Synopsis
- The study investigates the outcomes of a new treatment approach (reverse sequence of neoadjuvant chemotherapy, radiation, mastectomy, and reconstruction) for locally advanced breast cancer compared to the standard treatment sequence.
- In a retrospective analysis of 222 female patients under 65, results showed no significant differences in overall survival (OS) and recurrence-free survival (RFS) between the two methods, with 5-year OS rates of 88.4% for the reverse sequence and 81.5% for the standard.
- Patients in the reverse sequence group experienced shorter overall treatment times, and complication rates were similar between groups, suggesting that this alternative can be safely considered for certain patients.