Lack of efficacy of tocilizumab in acute exacerbation of pulmonary fibrosis.

https://bit.ly/3ClggYb.

Articular manifestations related to anti-interleukin-5 therapies in severe asthma: a case series.

https://bit.ly/3vfPn4k.

New Dominant-Negative IL6ST Variants Expand the Immunological and Clinical Spectrum of GP130-Dependent Hyper-IgE Syndrome.

Patients with autosomal dominant (AD) hyper-IgE syndrome (HIES) suffer from a constellation of manifestations including recurrent bacterial and fungal infections, severe atopy, and skeletal abnormalities. This condition is typically caused by monoallelic dominant-negative (DN) STAT3 variants. In 2020, we described 12 patients from eight kindreds with DN IL6ST variants resulting in a new form of AD HIES.

Outcomes and risk factors with COVID-19 or influenza in hospitalized asthma patients.

Background: At the time of the SARS-CoV-2 emergence, asthma patients were initially considered vulnerable because respiratory viruses, especially influenza, are associated with asthma exacerbations, increased risk of hospitalization and more severe disease course. We aimed to compare the asthma prevalence in patients hospitalized for COVID-19 or influenza and risk factors associated with poor prognosis with the diseases.

Methods: This retrospective cohort study used the Paris university hospitals clinical data warehouse to identify adults hospitalized for COVID-19 (January to June 2020) or influenza (November 2017 to March 2018 for the 2017-2018 influenza period and November 2018 to March 2019 for the 2018-2019 period).

[New developments in the diagnosis and management of adult asthma].

NEW DEVELOPMENTS IN THE DIAGNOSIS AND MANAGEMENT OF ADULT ASTHMA Asthma management must be comprehensive, focusing on control¬ling symptoms with inhaled corticosteroids adapted to the stage of severity, but also on limiting the occurrence of exacerbations by correcting poor control factors and educating the patient. The diagnosis of asthma is not only clinical, but it must also include a measurement of respiratory function. Research is active in the field of asthma, with the development of new strategies for prescribing inhaled corticosteroids, which are simpler for patients, but which prescribers must take on board in order to control them.

[Asthma exacerbations in adults: Preventing and treat].

Exacerbations of asthma are still responsible for 900 deaths per year in France, most of which are considered preventable. They have a major impact on the quality of life of patients and are responsible for a large part of the socio-economic cost of asthma in France. Exacerbations of asthma can be partly prevented by inhaled corticosteroid treatment as controller therapy, at a dose adapted to the level of control of symptoms and the management of aggravating factors.