Publications by authors named "Mathilde Calvez"
Article Synopsis
- There is a lack of research on psychiatric emergencies in older adults over 60, especially in Europe, prompting a study at a major French psychiatric emergency center.
- The study involved 300 older patients, predominantly women, many with a history of psychiatric issues, commonly presenting with depression, anxiety, and suicidal thoughts.
- Findings indicated that 39% of these patients were hospitalized, with factors like past hospitalizations, suicidal tendencies, and certain psychiatric diagnoses being key predictors of hospitalization.
Article Synopsis
- HIV-1 does not infect neurons directly but affects brain glial cells, leading to neurotoxicity and inflammation that harm neurons despite antiretroviral treatment.
- Osteopontin (OPN), a proinflammatory protein, is elevated in the brains of those with HIV-associated cognitive disorders, but its effects on neuronal function are not well understood.
- This study reveals that OPN interacts with HIV's envelope protein and activates the mTOR pathway in neurons, impacting their structure and potentially influencing cognitive dysfunction in HIV-infected individuals.*
The anti-NeuN antibody has been widely used for over 15 years to unambiguously identify post-mitotic neurons in the central nervous system of a wide variety of vertebrates including mice, rats and humans. In contrast to its widely reported nuclear localization, we found significantly higher NeuN reactivity in the cytoplasm of neurons in brain sections from HIV-infected individuals with cognitive impairment compared to controls. The protein target of anti-NeuN antisera was recently identified as the neuron-specific RNA splicing factor, Rbfox3, but its significance in diseases affecting the brain has not been previously reported.
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