Residual Variation Intolerance Score Detects Loci Under Selection in Neuroinvasive .

is a Gram-positive bacterium that can be found in a broad range of environments, including soil, food, animals, and humans. can cause a foodborne disease manifesting as sepsis and meningo-encephalitis. To evaluate signals of selection within the core genome of neuroinvasive strains, we sequenced 122 strains from cerebrospinal fluid (CSF) of Dutch meningitis patients and performed a genome-wide analysis using Tajima's D and ω (dN/dS).