Publications by authors named "Mathieu Rouel"
Article Synopsis
- Aggressive B-cell malignancies like mantle cell lymphoma (MCL) depend on their microenvironment, and understanding these interactions can improve treatments.
- A transcriptomic analysis compared circulating MCL cells to those in lymph nodes, revealing that interleukin-32 beta (IL32β) is secreted in a microenvironment-dependent manner and is linked to tumor survival.
- The study found that IL32β influences monocyte polarization into MCL-associated macrophages, promoting tumor support, and showed that inhibiting the NIK/alternative-NFkB pathway can disrupt this survival mechanism.
In the sea urchin embryo, specification of the dorsal-ventral axis critically relies on the spatially restricted expression of nodal in the presumptive ventral ectoderm. The ventral restriction of nodal expression requires the activity of the maternal TGF-β ligand Panda but the mechanism by which Panda restricts nodal expression is unknown. Similarly, what initiates expression of nodal in the ectoderm and what are the mechanisms that link patterning along the primary and secondary axes is not well understood.
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