Publications by authors named "Mathieu Pourquie"
Article Synopsis
- Computational fluid dynamics (CFD) is utilized to study turbulence in abdominal aortic aneurysms (AAA), focusing on how hemodynamic parameters relate to aneurysm risk.
- The study reveals that during peak systole, a vortex ring forms in the AAA region and can destabilize into smaller vortices, which leads to turbulence and impacts blood flow patterns.
- The research indicates that the geometric changes of an AAA significantly alter flow dynamics, potentially influencing blood recirculation areas and the risk of thrombus formation.
Atherosclerosis develops in the arterial system at sites of low as well as low and oscillating shear stress. Previously, we demonstrated a shear-related distribution of ciliated endothelial cells in the embryonic cardiovascular system and postulated that the primary cilium is a component of the shear stress sensor, functioning as a signal amplifier. This shear-related distribution is reminiscent of the atherosclerotic predilection sites.
View Article and Find Full Text PDFHemodynamics play an important role in cardiovascular development, and changes in blood flow can cause congenital heart malformations. The endothelium and endocardium are subjected to mechanical forces, of which fluid shear stress is correlated to blood flow velocity. The shear stress responsive genes lung Krüppel-like factor (KLF2), endothelin-1 (ET-1), and endothelial nitric oxide synthase (NOS-3) display specific expression patterns in vivo during chicken cardiovascular development.
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