Publications by authors named "Mathieu Metivier"
Article Synopsis
- The study focuses on how asymmetric division of stem cells is crucial for keeping tissues balanced and involves precise chromosome separation during cell division.
- Researchers found that Polo kinase levels influence the timing of Cyclin B degradation, which is important for mitosis, and this process is regulated by other kinases like Aurora A and Aurora B.
- The findings suggest that the interaction between Aurora and Polo kinases helps in maintaining the balance of neural stem cells in Drosophila, which is important for normal brain function and preventing tumor growth.
Proper assembly of mitotic spindles requires microtubule nucleation not only at the centrosomes but also around chromatin. In this study, we found that the Drosophila tubulin-specific chaperone dTBCE is required for the enrichment of tubulin in the nuclear space after nuclear envelope breakdown and for subsequent promotion of spindle microtubule nucleation. These events depend on the CAP-Gly motif found in dTBCE and are regulated by Ran and lamin proteins.
View Article and Find Full Text PDFArticle Synopsis
- A new chemical called 1 works against the growth of cells that can cause problems, like cancer.
- It affects how the tiny structures inside cells, called microtubules, grow and stop the cells from dividing properly.
- This suggests that 1 could be a special medicine to help stop cell growth in both humans and other animals.
Ensconsin (also known as MAP7) controls spindle length, centrosome separation in brain neuroblasts (NBs) and asymmetric transport in oocytes. The control of spindle length by Ensconsin is Kinesin-1 independent but centrosome separation and oocyte transport require targeting of Kinesin-1 to microtubules by Ensconsin. However, the molecular mechanism used for this targeting remains unclear.
View Article and Find Full Text PDF