Publications by authors named "Mathieu Mahevas"
Article Synopsis
- A clinical trial was conducted to assess the effectiveness and safety of dexamethasone (DEX) alone versus combined with tocilizumab (TCZ) in patients with moderate-to-severe COVID-19 pneumonia requiring oxygen support.
- At day 14, the rates of mechanical ventilation or death were similar between the DEX group (14%) and the TCZ+DEX group (12%), indicating no significant improvement from the combination treatment.
- Despite no clear benefits in reducing mechanical ventilation or mortality with the TCZ+DEX treatment, both treatments had similar safety profiles; however, definitive conclusions are limited due to the broad confidence intervals in the results.
Purpose: To report four cases of life-threatening COVID-19 pneumonia in patients with high blood concentrations of neutralizing autoantibodies against type I interferons (IFNs), who were treated with plasma exchange (PE) as a rescue therapy.
Methods: Prospective case series, which included patients, diagnosed with RT-PCR-confirmed SARS-CoV-2 infection and positive autoantibodies against type I IFNs in two French intensive care units (ICUs) between October 8 and November 14, 2020. Six critically ill COVID-19 patients with no anti-IFN antibodies were used as controls.
Objective: To compare the efficacy of methotrexate (MTX) and mycophenolate mofetil (MMF) in the prevention of relapses in neurosarcoidosis.
Methods: We conducted a retrospective multicenter study including patients who received MTX or MMF for the treatment of histologically proven neurosarcoidosis. The efficacy of the immunosuppressive drug was assessed by determining the time to relapse.
Objective: Autoinflammatory disorders are caused by a primary dysfunction of the innate immune system. Among these disorders are hereditary recurrent fevers, which are characterized by recurrent episodes of fever and inflammatory manifestations affecting multiple tissues. Hereditary recurrent fevers often lack objective diagnostic criteria, thereby hampering the identification of disease-causing genes.
View Article and Find Full Text PDFBackground And Objectives: Sarcoidosis is a multisystem disorder of unknown etiology. The outcome of renal transplantation on patients with sarcoidosis is not well known. A few case reports have described recurrence of sarcoidosis after transplant.
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