A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.

Background: Clostridium difficile is the leading cause of hospital-borne infections occurring when the natural intestinal flora is depleted following antibiotic treatment. Current treatments for Clostridium difficile infections present high relapse rates and new hyper-virulent and multi-resistant strains are emerging, making the study of this nosocomial pathogen necessary to find novel therapeutic targets.

Results: We present iMLTC806cdf, an extensively curated reconstructed metabolic network for the C.