Altered topological blueprint of trabecular bone associates with skeletal pathology in humans.

Bone is a hierarchically organized biological material, and its strength is usually attributed to overt factors such as mass, density, and composition. Here we investigate a covert factor - the topological blueprint, or the network organization pattern of trabecular bone. This generally conserved metric of an edge-and-node simplified presentation of trabecular bone relates to the average coordination/valence of nodes and the equiangular 3D offset of trabeculae emanating from these nodes.

Experimental setup for developing acousto-electric interaction imaging.

Acousto-Electric Interaction (AEI) is a physical phenomenon identified in the literature as potentially useful for imaging the electrical conductivity of biological tissues. AEI could lead to a non-invasive technique for detecting breast tumors, since the conductivity of pathological tissues differs significantly from the conductivity of healthy breast tissues. Applying AEI to image heterogeneous structures of the size of the breast represents a major technical challenge.