Publications by authors named "Mathieu Dewez"
Article Synopsis
- - The study explores the relationship between the HLA genotype and disease susceptibility, emphasizing that typing resolution for HLA genes varies based on the disease and existing knowledge of HLA alleles involved.
- - Researchers tested a new nanopore sequencing method by Omixon Biocomputing Ltd as an alternative to the traditional sequence-specific oligoprobe (SSO) technique for HLA typing, focusing on specific diseases like rheumatoid arthritis and diabetes.
- - Results showed that the nanopore approach achieved 100% concordance with the SSO method across all tested HLA loci, making it a suitable option for routine diagnostics in HLA and disease associations.
Article Synopsis
- Current HLA genotyping for deceased donors faces challenges due to time constraints and limited resolution, which complicates compatibility assessments for sensitized recipients.
- This study introduces a customized protocol using the NanoTYPE® HLA typing kit and MinION® sequencer, allowing for rapid and accurate HLA typing of deceased donors in about 3.75 hours with high precision.
- The improved method enhances organ allocation security, especially for sensitized recipients with complex HLA profiles, and addresses technical challenges, potentially transforming deceased donor genotyping and organ allocation strategies.
