Publications by authors named "Mathieu De Jode"
Infections due to antimicrobial-resistant bacteria have become a major threat to global health. Some patients may carry resistant bacteria in their gut microbiota. Specific risk factors may trigger the conversion of these carriages into infections in hospitalized patients.
View Article and Find Full Text PDFIn contrast to the many reports of successful real-world cases of personalized bacteriophage therapy (BT), randomized controlled trials of non-personalized bacteriophage products have not produced the expected results. Here we present the outcomes of a retrospective observational analysis of the first 100 consecutive cases of personalized BT of difficult-to-treat infections facilitated by a Belgian consortium in 35 hospitals, 29 cities and 12 countries during the period from 1 January 2008 to 30 April 2022. We assessed how often personalized BT produced a positive clinical outcome (general efficacy) and performed a regression analysis to identify functional relationships.
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- The immune system uses various methods to fight harmful microbes, with neutrophils as a key first line of defense that can kill or trap pathogens.
- Recent studies recognize bacteriophages, which are abundant in the human microbiome, as potential antibacterial treatments, but their effects on neutrophils are not well understood.
- This study found that exposing human neutrophils to the phage PAK_P1 increased interleukin-8 (IL-8) secretion without causing cell death or affecting other immune responses, suggesting that phages might enhance certain immune functions without triggering harmful inflammation.
We report the sequence of the Streptococcus pyogenes emm28 strain M28PF1, isolated from a patient with postpartum endometritis. The M28 protein is smaller than that of MGAS6180 (NC_007296.1).
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