Publications by authors named "Mathieu A F Claireaux"
Article Synopsis
- Sequencing B-cell and T-cell receptors helps us learn about the immune response but doesn't give details on their affinity or specificity.
- A new multiscale model is presented to better understand B-cell repertoires by comparing simulated results with actual experimental data.
- Findings indicate that clonal abundance doesn't necessarily correlate with affinity, and even low-abundance clones may possess high affinity, guiding future research approaches.
Infants may develop severe viral respiratory tract infections because their immune system is still developing in the first months after birth. Human milk provides passive humoral immunity during the first months of life. During the COVID-19 pandemic, circulation of common respiratory viruses was virtually absent due to the preventative measures resulting in reduced maternal exposure.
View Article and Find Full Text PDFAffinity maturation is an evolutionary process by which the affinity of antibodies (Abs) against specific antigens (Ags) increases through rounds of B-cell proliferation, somatic hypermutation, and positive selection in germinal centres (GC). The positive selection of B cells depends on affinity, but the underlying mechanisms of affinity discrimination and affinity-based selection are not well understood. It has been suggested that selection in GC depends on both rapid binding of B-cell receptors (BcRs) to Ags which is kinetically favourable and tight binding of BcRs to Ags, which is thermodynamically favourable; however, it has not been shown whether a selection bias for kinetic properties is present in the GC.
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