Publications by authors named "Mathias van Hemelrijck"

Article Synopsis
  • The study examines the relationship between oral bacteria and infective endocarditis (IE), highlighting the shift in antibiotic prophylaxis (AP) guidelines in 2007/2008 that limited AP to high-risk patients only.
  • Researchers analyzed data from University Hospital Zurich (2000-2022) to determine if oral streptococcal IE cases rose in moderate-risk patients following these guideline changes.
  • Results showed that moderate-risk patients had a significantly higher risk of oral streptococcal IE after the guidelines were updated, suggesting that expanding AP to include certain moderate-risk groups, particularly those with congenital valve anomalies, may be necessary.*
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  • A study involving 302 cases of prosthetic valve endocarditis (PVE) showed a one-year mortality rate of 31%.
  • Early-onset PVE (within 6 months of valve surgery) did not result in worse outcomes compared to late-onset PVE, with mortality rates of 21% versus 32% (p=0.126).
  • Both early and late-onset categories required similar rates of redo valve surgeries.
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  • Diagnosing infective endocarditis (IE) is complex, and this study compared the effectiveness of the 2015 and 2023 Duke clinical criteria for diagnosing the condition.
  • Conducted in two Swiss University Hospitals, researchers analyzed data from 3127 patients suspected of having IE, with 1177 confirmed cases, to assess the agreement between the clinical criteria and expert diagnoses.
  • Results showed that the 2023 criteria had a higher sensitivity (69%) compared to the 2015 criteria (59%), although both versions categorized about one-third of episodes as possible IE.
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Objectives: Aortic arch or aortic root replacement is not performed in all cases of acute type A aortic dissection (ATAD), and a second aortic procedure will become necessary over time for some patients. Indications and outcomes, of second aortic procedures have not been studied extensively.

Methods: Characteristics and in-hospital outcomes of all patients undergoing surgical repair for type A acute aortic dissection were analysed and patients needing second aortic procedure during follow-up were identified.

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Background: To identify 18F-fluorodeoxyglucose (FDG) uptake patterns in positron emission tomography/computed tomography (PET/CT) caused by infection, inflammation, surgical material, and/or graft coating.

Methods And Results: Of 610 consecutive patients with thoracic aortic graft surgery, 60 patients with 187 PET/CT were retrospectively included. We quantified FDG uptake in all grafts using maximum standardized uptake value (SUVmax) alone and in relation to liver background (SUVratio) and determined the uptake pattern.

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Article Synopsis
  • The study assessed the diagnostic effectiveness of the Duke-ISCVID 2023 criteria for infective endocarditis (IE) against earlier versions from 2000 and 2015.
  • Conducted at two university hospitals between 2014 and 2022, it involved 2132 patients, 1101 of whom were confirmed to have IE.
  • Results showed the new criteria improved sensitivity to 84% (up from 70%) but decreased specificity to 60% (down from 74%), suggesting a need for further refinements to balance these diagnostic metrics.
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  • The Duke criteria for diagnosing infective endocarditis were updated in 2023, and this study evaluates their diagnostic accuracy, particularly for patients with Staphylococcus aureus bacteremia (SAB).
  • Analyzing data from 1344 SAB episodes, the revised 2023 criteria showed improved sensitivity (81% for Duke-ISCVID and 82% for Duke-ESC) compared to the 2015 version (75%), although specificity decreased from 99% to 96%.
  • The study highlights that while spondylodiscitis was more common in patients with SAIE, this trend was not significant when certain criteria were excluded, indicating the need for further research on the new criteria's components.
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Vascular graft/endograft infection (VGEI) is a constant in cardiovascular surgery with published rates between 1 and 5%. Every graft type and anatomical location is a potential target for infectious complications. These patients are sick patients with high frailty burden.

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Introduction: Around 25% of patients with left-sided infective endocarditis and operative indication do not undergo surgery. Baseline characteristics and outcomes are underreported. This study describes characteristics and outcomes of surgical candidates with surgical intervention or medical treatment only.

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Objectives: Aortic valve-sparing root replacement (AVSRR) is a technically demanding procedure. In experienced centers it offers excellent short- and long-term results, making the procedure an attractive alternative for aortic root replacement especially in young patients. The aim of this study was to analyze long-term results of AVSRR using the David operation in our institution over the last 25 years.

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Background: Older age and female sex are thought to be risk factors for adverse outcomes after repair of acute type A aortic dissection (AAAD). The aim of this study is to analyze age- and sex-related outcomes in patients undergoing AAAD repair.

Methods: Retrospective analysis of patients undergoing emergency AAAD repair.

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Acute aortic syndrome includes a group of serious aortic pathologies, with a mortality rate of up to 90% in the first 40 days after the onset of symptoms. Depending on the location of the lesion, the treatment will be medical or surgical which has been shown to improve the prognosis of these patients both in the short- and long-term. Timey diagnosis is essential to increase survival and decrease the rate of related complications; however, due to the low incidence and sometimes non-specific clinical picture, the diagnosis can be delayed or missed, leading to catastrophic consequences for the patients.

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Objectives: Oral anticoagulation prior to emergency surgery is associated with an increased risk of perioperative bleeding, especially when this therapy cannot be discontinued or reversed in time. The goal of this study was to analyse the impact of different oral anticoagulants on the outcome of patients who underwent emergency surgery for acute type A aortic dissection (ATAAD).

Methods: This was a single-centre retrospective study of patients treated with oral anticoagulation at the time of surgery for ATAAD.

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We report the case of a 78-year-old female patient who had a PASCAL device implanted for severe degenerative mitral regurgitation. Intraprocedural echocardiography revealed persistent severe mitral regurgitation due to device dislocation. Implanting another device was not possible.

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Article Synopsis
  • - Fungal osteomyelitis is a rare but serious infection that can occur after cardiac surgery, leading to high mortality rates.
  • - A case study of a 60-year-old man with osteomyelitis following the implantation of a left ventricular assist device illustrated the challenges of diagnosis and treatment, involving microbiological tests and imaging scans.
  • - Despite initial treatments like antifungal medications and wound therapy failing, the patient ultimately recovered after undergoing total sternectomy and pectoralis flap reconstruction, showing that a combination of surgery and antifungal therapy may be effective.
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Surgical implantation of a complete or incomplete ring to reduce the valve annulus and improve leaflet coaptation is the mainstay of mitral valve surgery. The Cardioband® system (Edwards Lifesciences) was designed to address the pathophysiological mechanism of annular dilatation through a catheter-based approach. We present the histopathological workup of a Cardioband® device, which had been implanted 21 months earlier in a 34-year-old male with ischemic cardiomyopathy.

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Hemoadsorption was used in a 59-year-old patient with an acute type A aortic dissection, who was on rivaroxaban and dual antiplatelet therapy with clopidogrel and acetylsalicylic acid. Our aim was to expeditiously remove rivaroxaban preoperatively. After 8 h of hemoadsorption, the rivaroxaban blood plasma concentration (RBPC) did not decrease below 42.

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Training in cardiac surgery is a cumbersome topic. Over the last years, major cardiac surgical operations have been found to decrease due to the increasing number in transcatheter interventions. Becoming a cardiac surgeon has become partly a hard task.

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Mitral annular calcification (MAC) is a chronic degenerative process that implies calcification on the mitral support structure. It usually appears as a bystander to other cardiac pathologies hindering surgical treatment and increasing morbidity and mortality. When addressing the mitral valve, many surgical strategies have been suggested in the past with no clear consensus on what to choose.

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Objective: To compare the outcomes of MitraClip and surgical mitral repair in low-intermediate risk elderly patients affected by degenerative mitral regurgitation (DMR).

Methods: We retrospectively selected patients aged ≥75 years, with Society of Thoracic Surgeons Predicted Risk Of Mortality (STS-PROM) <8%, submitted to MitraClip (n = 100) or isolated surgical repair (n = 206) for DMR at 2 centers between January 2005 and May 2017. To adjust for baseline imbalances, we used a propensity score model for average treatment effect on survival.

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