Publications by authors named "Mathias Schneeweiss-Gleixner"

Background: Gastrointestinal dysfunction is a common complication of medical nutrition therapy in critically ill patients. Whether prone positioning leads to a deterioration in gastrointestinal function has not been fully clarified. Thus, we aimed to analyze the influence of prone positioning on the tolerance of medical nutrition therapy.

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  • A study aimed to evaluate the prevalence and factors related to cholestasis in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) revealed that 53% of the 225 patients developed cholestasis during their ICU stay.
  • The analysis identified that higher levels of certain liver enzymes, inflammation markers, and the use of specific treatments like extracorporeal membrane oxygenation and ketamine were linked to the development of cholestasis.
  • Cholestasis was found to be a negative prognostic indicator, as its presence and peak alkaline phosphatase levels were associated with poorer survival rates in the ICU and at six months post-treatment.
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  • * The study found that CytoSorb treatment significantly reduced levels of bilirubin, procalcitonin, and interleukin-6, which are key biomarkers in ACLF, with ICU survivors showing better relative improvements.
  • * No severe complications were linked to CytoSorb, suggesting its safety; however, further prospective research is needed to fully understand its impact on the clinical outcomes of ACLF patients with high cytok
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Refeeding syndrome (RFS) is a potentially life-threatening complication in malnourished (critically ill) patients. The presence of various accepted RFS definitions and the inclusion of heterogeneous patient populations in the literature has led to discrepancies in reported incidence rates in patients requiring treatment at an intensive care unit (ICU). We conducted a prospective observational study from 2010 to 2013 to assess the RFS incidence and clinical characteristics among medical ICU patients at a large tertiary center.

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Objectives: Patients with systemic rheumatic diseases (SRDs) are at risk of admission to the intensive care unit (ICU). Data concerning these critically ill patients are limited to few retrospective studies.

Methods: This is a single-centre retrospective study of patients with SRDs admitted to an ICU at the Vienna General Hospital between 2012 and 2020.

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Treatment of acute respiratory distress syndrome (ARDS) represents a severe complication of coronavirus disease 2019 (COVID-19) infection and is often challenging in intensive care treatment. Potential positive effects of intravenous cyclophosphamide have been reported in interstitial lung diseases (ILDs). However, there are no data on the use of high-dose cyclophosphamide in therapy-resistant COVID-19 ARDS.

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Background: Patients receiving extracorporeal membrane oxygenation (ECMO) support are at high risk for malnutrition. There are currently no general nutrition guidelines for coronavirus disease 2019 (COVID-19) patients during ECMO therapy.

Methods: We conducted a retrospective analysis of COVID-19 patients requiring venovenous ECMO support at a large tertiary hospital center.

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In most patients with advanced systemic mastocytosis (AdvSM), neoplastic mast cells (MC) express D816V. However, despite their disease-modifying potential, KIT D816V-targeting drugs, including midostaurin and avapritinib, may not produce long-term remissions in all patients. Cyclin-dependent kinase (CDK) 4 and CDK6 are promising targets in oncology.

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Background And Aims: Cholestasis is associated with disease severity and worse outcome in COVID-19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been described.

Approach And Results: Hospitalized patients with COVID-19 between 03/2020 and 07/2021 were included.

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Background: Duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) affects outcome in acute respiratory distress syndrome (ARDS). In coronavirus disease 2019 (COVID-19) related ARDS, the role of pre-ECMO IMV duration is unclear. This single-centre, retrospective study included critically ill adults treated with ECMO due to severe COVID-19-related ARDS between 01/2020 and 05/2021.

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  • * A 2019 Working Conference in Vienna aimed to address the lack of comprehensive classification and diagnostic criteria for these neoplasms in dogs, leading to the development of a new proposed classification system.
  • * The article outlines refined grading and staging criteria for mast cell tumors, aimed at improving diagnostic evaluation and management, which could also aid in clinical trials.
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Ponatinib is a tyrosine kinase inhibitor (TKI) directed against BCR-ABL1 which is successfully used in patients with + chronic myeloid leukemia (CML). However, compound mutations may develop during therapy in these patients and may lead to drug resistance. Asciminib is a novel drug capable of targeting most BCR-ABL1 mutant-forms, including BCR-ABL1, but remains ineffective against most BCR-ABL1+ compound mutation-bearing sub-clones.

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  • * MDS patients with -variants showed higher median serum ferritin levels and a faster increase in ferritin over time, particularly in those with refractory anemia subtypes.
  • * Patients with -variants, especially H63D and C282Y, exhibited longer progression-free survival compared to non-mutated patients, suggesting a potential clinical significance of these variants in MDS outcomes.
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The recent outbreak of coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a world-wide pandemic. Disseminated lung injury with the development of acute respiratory distress syndrome (ARDS) is the main cause of mortality in COVID-19. Although liver failure does not seem to occur in the absence of pre-existing liver disease, hepatic involvement in COVID-19 may correlate with overall disease severity and serve as a prognostic factor for the development of ARDS.

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Purpose: Ponatinib is the only approved tyrosine kinase inhibitor (TKI) suppressing BCR-ABL1-mutated cells in chronic myeloid leukemia (CML). However, due to side effects and resistance, BCR-ABL1-mutated CML remains a clinical challenge. Hydroxyurea (HU) has been used for cytoreduction in CML for decades.

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