Publications by authors named "Mathias S Renaud"
Sequence-specific gene regulation by small RNA (sRNA) pathways is essential for the development and function of organisms in all domains of life. These regulatory complexes, containing an Argonaute protein (AGO) guided by a bound sRNA, have the potential to regulate thousands of individual target transcripts at both the co- and post-transcriptional level. Determining the repertoire of transcripts that an AGO is capable of regulating in a particular context is essential to understanding the function of these regulatory modules.
View Article and Find Full Text PDFIn this issue of Developmental Cell, Cornes et al. show that piRNAs initiate transcriptional silencing of spermatogenesis genes in the C. elegans germline via an endogenous nuclear RNAi pathway.
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- The Caenorhabditis elegans genome contains nineteen Argonaute proteins that utilize various small RNAs for regulating gene expression, with CSR-1 being the only essential one under lab conditions.
- The CSR-1 locus produces two protein isoforms (CSR-1a and CSR-1b), which differ by 163 amino acids, and have distinct expression patterns; CSR-1a is expressed in specific tissues like the intestine and during spermatogenesis, while CSR-1b is found in the germline.
- Research using CRISPR-Cas9 and small RNA sequencing reveals that CSR-1a is involved in tissue-specific functions, including regulating fertility and immune responses, indicating the necessity of studying both iso
Cophylogeny is the congruence of phylogenetic relationships between two different groups of organisms due to their long-term interaction. We investigated the use of tree shape distance measures to quantify the degree of cophylogeny. We implemented a reverse-time simulation model of pathogen phylogenies within a fixed host tree, given cospeciation probability, host switching, and pathogen speciation rates.
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