Light-Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi-Chronic Study in Cortical Cell Culture and Rat Model.

Neurostimulation employing photoactive organic semiconductors offers an appealing alternative to conventional techniques, enabling targeted action and wireless control through light. In this study, organic electrolytic photocapacitors (OEPC) are employed to investigate the effects of light-controlled electric stimulation on neuronal networks in vitro and in vivo. The interactions between the devices and biological systems are characterized.

Shedding Light on Cardiac Excitation: In Vitro and In Silico Analysis of Native Ca Channel Activation in Guinea Pig Cardiomyocytes Using Organic Photovoltaic Devices.

Objective: This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels (I) in Guinea pig ventricular cardiomyocytes.

Methods: Whole-cell patch-clamp recordings were employed to examine light-triggered OEPC mediated I activation, integrating the channel's kinetic properties into a multicompartment cell model to take intracellular ion concentrations into account.

A system theory based digital model for predicting the cumulative fluid balance course in intensive care patients.

Surgical interventions can cause severe fluid imbalances in patients undergoing cardiac surgery, affecting length of hospital stay and survival. Therefore, appropriate management of daily fluid goals is a key element of postoperative intensive care in these patients. Because fluid balance is influenced by a complex interplay of patient-, surgery- and intensive care unit (ICU)-specific factors, fluid prediction is difficult and often inaccurate.

Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration?-A Systematic Review.

Background: Peripheral nerve injuries affect over 2% of trauma patients and can lead to severe functional impairment and permanent disability. Autologous nerve transplantation is still the gold standard in the reconstruction of nerve defects. For small defects, conduits can be considered for bridging.