Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging.

Aims: The time-to-treatment, ST-segment resolution (STR), and TIMI-flow might be associated with infarct size (IS) and infarct transmurality in humans. Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations.

Methods And Results: This study analysed 135 ST-elevation myocardial infarction (STEMI) patients randomized to prehospital fibrinolysis or prehospital initiated facilitated percutaneous coronary intervention (PCI).

Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging.

Objectives: The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI).

Background: Infarct size measurements can be used as surrogate end point to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction (MI). Delayed enhancement MRI is a rather new technique, and so far infarct IS reproducibility has not been established appropriately.

Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction.

Aims: Early and complete reperfusion is the main treatment goal in ST-elevation myocardial infarction (STEMI). The timely optimal reperfusion strategy might be a pre-hospital initiated pharmacological reperfusion with subsequent facilitated percutaneous coronary intervention (PCI). This approach has been compared with pre-hospital combination-fibrinolysis only to determine whether either one of these methods offer advantages with respect to final infarct size.