Publications by authors named "Mathias D'Souza"
Article Synopsis
- Finite element studies of the tibiofemoral joint have gained traction, focusing on how different ways of modeling the meniscus can impact knee mechanics.
- A sensitivity analysis was conducted with various specimen-specific and generic models to evaluate how meniscus shape, alignment, and attachment affect contact mechanics and meniscus movement.
- The findings indicated that factors like meniscus shape and knee alignment significantly impacted knee mechanics more than material properties or attachment positions, emphasizing the need for diverse geometrical representations in clinical studies.
Computational prediction tools have been developed to aid in the interpretation of novel sequence variations, but their utility within the diagnostic setting of antithrombin (AT) deficiency has not been evaluated to date. The aim of our study was to test the performance of different bioinformatic tools (Meta-SNP, MutPred, nsSNPAnalyzer, PANTHER, PhD-SNP, PMut, SIFT, SNAP, SNPs&Go, PolyPhen-2, PON-P2, and PredictSNP) in predicting the pathogenicity of AT sequence variations. We analysed all naturally occurring SERPINC1 missense mutations that have been previously characterised to be damaging with regard to the secretion or function of the AT molecule.
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