Network pharmacology, molecular docking and experimental approaches of the anti-proliferative effects of ethyl-acetate extract in cervical cancer cells.

Background: Cervical cancer, one of the lethal cancers among women, is a challenging disease to treat. The current therapies often come with severe side effects and the risk of resistance development. Traditional herbal medicine, with its potential to offer effective and less toxic options, is a promising avenue.

The impact of Bacillus thuringiensis var. israelensis (Vectobac WDG) larvicide sprayed with drones on the bio-control of malaria vectors in rice fields of sub-urban Kigali, Rwanda.

Background: The core vector control tools used to reduce malaria prevalence are currently long-lasting insecticidal nets (LLINs), and indoor residual spraying (IRS). These interventions are hindered by insecticide resistance and behavioural adaptation by malaria vectors. Thus, for effective interruption of malaria transmission, there is a need to develop novel vector control interventions and technologies to address the above challenges.

Hypoglycemic and Antioxidant Activities of Dichloromethane Extract of .

Diabetes mellitus is a chronic metabolic disorder which has greatly led to an increase in morbidity and mortality globally. Although is widely used for the management of diabetes among the Embu and Mbeere communities in Kenya, it has never been empirically evaluated for its hypoglycemic activity. This study was carried out to verify the hypoglycemic activity of dichloromethane (DCM) extract of as well as its antioxidant activity using various techniques.

In vivo ameliorative effects of vitamin E against hydralazine-induced lupus.

Objective: In this study, we investigated the in vivo ameliorative effects of vitamin E in a hydralazine-induced lupus model, which closely resembles SLE in humans. We aim to shed light on its potential as a therapeutic agent for managing SLE.

Methods: Forty BALB/c mice were used in this study.

Cognition Enhancing Potential of Aqueous Leaf Extract of in Mice.

is a vegetable consumed for its nutritional content in Kenya. In herbal medicine, is utilized to relief fever, anemia and hemorrhage. Additionally, it is utilized to manage cognitive dysfunction and is considered to augment brain function, but there is no empirical evidence to support this claim.

Antiproliferative Effects and Phytochemical Characterization of ((Forssk) Vahl) and (Eckyl and Zeyh) Extracts.

Cancer mortality is a global concern. The current therapeutic approaches despite showing efficacy are characterized by several limitations. Search for alternatives has led to the use of herbal plants including and .

Antibacterial properties and GC-MS analysis of ethyl acetate extracts of (Baker) and (Fresen).

Conventional antibiotics are associated with various side-effects. Therefore, there is need of using plant-derived antibiotics with fewer side-effects. and , which have been extensively utilized in the Mbeere community, were studied to support their folkloric use and demonstrate their antibacterial capabilities.

antioxidant activities of ((Forssk) Vahl) and (Eckyl. & Zeyh) extracts.

Herbal medications are gaining popularity due to their long history of use in traditional medicine. They serve as a reservoir for a diverse array of phytocompounds linked to amelioration of oxidative stress. Oxidative stress is a disturbance in the balance between generation and elimination of reactive species in human body.

Cognitive enhancing effects and anticholinesterase activity of stem bark and leaf extracts of .

Alzheimer's disease is ranked among the top five causes of death for old people. Globally, it is approximated that there are 7.7 million new cases of Alzheimer's disease per annum and it is expected that by the year 2050, as many as 1.

Targeted mutagenesis of the gene CRISPR/Cas9-mediated genome editing results in lower levels of cyanide in cassava.

Cassava is the world's most essential food root crop, generating calories to millions of Sub-Saharan African subsistence farmers. Cassava leaves and roots contain toxic quantities of the cyanogenic glycoside linamarin. Consumption of residual cyanogens results in cyanide poisoning due to conversion of the cyanogens to cyanide in the body.

GC-MS Analysis, Antibacterial and Antioxidant Potential of Ethyl Acetate Leaf Extract of (Delile) Grown in Kenya.

Bacterial diseases are a leading cause of mortality and morbidity globally. During bacterial diseases, an elevation of host immune response occurs, which involves the production of free radicals in response to the bacterial infection. The overproduction of free radicals in excess of the antioxidants leads to oxidative stress.

Antioxidant, Anti-Inflammatory, Acute Oral Toxicity, and Qualitative Phytochemistry of The Aqueous Root Extract of (Hochst. Ex Oliv. & Hiern.).

The root and leaf extracts of have been locally used in traditional medicine for decades to manage inflammatory conditions and other oxidative-stress-related syndromes; however, their pharmacologic efficacy has not been scientifically investigated and validated. Accordingly, we investigated the antioxidant activity, anti-inflammatory ( and ) efficacy, acute oral toxicity, and qualitative phytochemical composition of the aqueous root extract of . The ferric-reducing antioxidant power (FRAP) and the 2,2-diphenyl-2-pycrylhydrazyl (DPPH) radical scavenging test methods were used to determine the studied plant extract's antioxidant activity.

Hemoglobin Precipitation: An Index of Vasoconstrictive Activities of Methanol Leaf Extracts of C Hutch and Linn.

The function of innate hemostasis aids the body in bleeding control, preventing the loss of excessive amounts of blood following low-degree injuries. However, injuries of a higher degree may require extrinsic intervention to stop life-threatening blood loss. Astringent agents' actions result in mechanical constriction of small blood vessels and shrinkage of body tissues, thereby stopping blood loss.

Anti-inflammatory potential of dichloromethane leaf extracts of (Labill) and (Fresenius) in mice.

Background: Inflammation is an immune response characterized by swelling, redness, pain and heat. Inflammation is mainly managed using conventional medicines that are associated with many side effects. Plant-based remedies are considerably better alternative therapies for they have fewer side effects.

anti-inflammatory, anti-nociceptive, and antioxidant efficacy, and acute oral toxicity effects of the aqueous and methanolic stem bark extracts of (Harms.).

Oxidative stress causes and drives many agonising inflammatory conditions, which cause disability, financial burden, and emotional stress. The current anti-inflammatory, analgesic, and antioxidant agents are associated with adverse effects, inaccessibility, high costs, and low efficacies, thereby warranting the need for alternatives, especially from natural sources. plant is traditionally used in Kenyan communities to treat various inflammatory and oxidative stress-associated diseases; however, its pharmacologic efficacy and safety have not been empirically validated, hence this study.

In Vitro Antioxidant Activities of Methanolic Extracts of Harms., O. Hoffm., and De Wild.

Oxidative stress is the result of the disparity between pro-oxidants and antioxidants in an organism, and it is important in the pathogenesis of several degenerative disorders, such as arthritis, Alzheimer's, cancer, and cardiovascular diseases. Free radicals can damage biomolecules, such as nucleic acids, lipids, proteins, polyunsaturated fatty acids, and carbohydrates, and the DNA leading to mutations. The use of antioxidants is effective in delaying the oxidation of biomolecules.

Screening of the Dichloromethane: Methanolic Extract of for Antibacterial Activities against , , , , and .

Bacterial infections are responsible for a large number of deaths every year worldwide. On average, 80% of the African population cannot afford conventional drugs. Moreover, many synthetic antibiotics are associated with side effects and progressive increase in antimicrobial resistance.

In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of (Schum.).

Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Free radicals attack biologically important biomolecules, impairing their functioning, thereby initiating and exacerbating diseases. As a comeback, antioxidant therapies have been proposed as novel approaches to ameliorating oxidative stress-associated diseases including chronic ones.

Cognitive-Enhancing, Malondialdehyde-Lowering Activities and Phytochemical Profiles of Aqueous and Methanolic Stem Bark Extracts of (Schum.).

Cognitive impairment (CI) is among the leading causes of disability in humans. It is estimated that over 35.6 million people are suffering from Alzheimer's disease- (AD-) associated cognitive deficits globally with these statistics projected to rise over 115.

Effects of DCM Leaf Extract of (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats.

Obesity is the main component of metabolic syndromes involving distinct etiologies that target different underlying behavioral and physiological functions within the brain structures and neuronal circuits. An alteration in the neuronal circuitry stemming from abdominal or central obesity stimulates a cascade of changes in neurochemical signaling that directly or indirectly mediate spontaneously emitted behaviors such as locomotor activity patterns, anxiety, and exploration. Pharmacological agents available for the treatment of neurologic disorders have been associated with limited potency and intolerable adverse effects.

Antipyretic potential of dichloromethane leaf extract of (Labill) and (Fresenius) in rats models.

Introduction: Fever is managed using synthetic drugs such as aspirin, paracetamol among others. Synthetic drugs are associated with many side effects. Herbal medicines form alternative therapy since they possess fewer side effects and are readily available This study aimed to determine antipyretic potential of DCM extracts of and in Swiss albino rats.

Anti-obesity effects of dichloromethane leaf extract of in high fat diet-induced obese rats.

Background: Obesity is a chronic metabolic disorder characterized by increased adipose tissue mass due to positive energy balance. Prescription of anti-obesity drugs can be useful adjuncts to diet and exercise for obese patients who have failed to achieve weight loss. However, these drugs are ineffective and are associated with adverse effects.

In Vitro Antioxidant Properties of Dichloromethanolic Leaf Extract of (Fresen) as a Promising Antiobesity Drug.

The acquisition of ethnobotanical information from traditional practitioners remains an empirical aspect of understanding the ethnopharmacology research. However, integration of information on chemical composition of plant extracts and their pharmacological activities forms a key resource for synthesis of new and effective therapeutics. In traditional African medicine, has folkloric remedies against obesity and its associated oxidative stress-mediated complications.

Modulation of Cognition: The Role of on Spatial Learning and Memory Retention in High-Fat Diet-Induced Obese Rats.

Chronic exposures to high-fat diets are linked to neuropathological changes that culminate in obesity-related cognitive dysfunction and brain alteration. Learning, memory performance, and executive function are the main domains affected by an obesogenic diet. There are limited effective therapies for addressing cognitive deficits.

Antiobesity Activities of Methanolic Extracts of , , and in Progesterone-Induced Obese Mice.

, and are traditionally used to manage obesity in Kenya but lack scientific validation to support their use. The aim of this study was to determine the antiobesity activity of methanolic leaf extracts of these plants in progesterone-induced obese mice. The activity of the methanolic leaf extracts was orally bioscreened in progesterone-induced obese mice at 200 mg/kg/bw and 400 mg/kg/bw.