Synopsis of recent research by authors named "Mathew Martin"
Mathew Martin's recent research focuses on advancing cancer drug discovery techniques, such as fragment-based drug discovery (FBDD) and targeted delivery systems for cytotoxic agents, to enhance drug selectivity and efficacy.
His work emphasizes the use of innovative biophysical and crystallographic methods, including thermal proteome profiling and ligand interaction mapping, which aid in identifying high-affinity drug candidates and their binding modes.
Additionally, Martin explores the structural and mechanistic variations in drug interactions, such as those involving poly(ADP-ribose) polymerase (PARP) inhibitors, to improve therapeutic strategies in various cancers.
