Publications by authors named "Mathew M Thompson"
Article Synopsis
- Rosiglitazone, a medication that activates certain cellular receptors, was tested in a mouse model to see if it could prevent the expansion and rupture of aortic aneurysms induced by high cholesterol and Angiotensin II.
- Mice treated with rosiglitazone both before and after the infusion of Angiotensin II showed significantly lower rates of fatal ruptures and reduced aortic size compared to control groups.
- The reduction in aortic issues was linked to decreased expression of inflammatory markers, suggesting that rosiglitazone may help manage aneurysm risks, but further research is needed to clarify how it works.
Background: Dextran-40 is effective in reducing postoperative Doppler-detectable embolization in patients undergoing carotid endarterectomy (CEA). Dextrans are thought to have antithrombotic and antiplatelet effects. The mode of action is unclear.
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