Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice.

The COVID-19 pandemic has raised the standard regarding the current vaccine development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines have proved their ability to induce strong immunogenicity and protective efficacy. We developed 1-methylpseudouridine-containing mRNA-LNP vaccines, expressing either the more conserved SARS-CoV-2 nucleoprotein (mRNA-N) or spike protein (mRNA-S), both based on the prototypic viral sequences. When combining both mRNA-S and mRNA-N together (mRNA-S+N), the vaccine showed high immunogenicity and broad protection against different SARS-CoV-2 variants, including wildtype, Delta, BA.

Biogeographical and diversification analyses of Indian pseudoscorpions reveal the Western Ghats as museums of ancient biodiversity.

The tropical forests of the Western Ghats (WG) of India are considered 'refugia' harbouring highly diverse and endemic taxa but these refugia are under immense anthropogenic pressure. Most phylogenetic studies have explained diversity patterns across the WG using vertebrates, however, the processes impacting the highly endemic invertebrate fauna are still poorly understood. Here we investigate the evolutionary history of an ancient and widespread arachnid lineage (Pseudoscorpiones: Chthoniidae: Tyrannochthoniini) in the WG through a variety of biogeographical and diversification analyses, including sequence data from three markers for 45 terminals from the WG and 22 from Africa, East and Southeast Asia, Australasia and the Neotropics.

SARS-CoV-2 Induces Cytokine Responses in Human Basophils.

Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine responses and in particular IL-13, in both resting and IL-3 primed basophils.

Boolean analysis of the transcriptomic data to identify novel biomarkers of IVIG response.

Intravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory to IVIG and require alternative treatments. Identifying a biomarker that could segregate IVIG responders from non-responders has been a subject of intense research. Unfortunately, previous transcriptomic studies aimed at addressing IVIG resistance have failed to predict a biomarker that could identify IVIG-non-responders.

On a new synonymy in the spider genus Nephila Leach, 1815 (Araneidae, Nephilinae) from India with supplementary notes on colour polymorphism in the genus.

The golden orb-weaving spider genus Nephila Leach, 1815 currently has four representatives in India: Nephila dirangensis Biswas Biswas, 2006, Nephila kuhlii (Doleschall, 1859), Nephila pilipes (Fabricius, 1793) and Nephila robusta Tikader, 1962 (World Spider Catalog 2020). While N. kuhlii has its type locality in Java (Doleschall 1859) and that of N.

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.

Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate of cardiovascular events. While cholesterol accumulation in atheroma plaque and macrophages is a major driver of the inflammatory process, the role of the LXR cholesterol sensors remains to be clarified. Murine and human macrophages were treated with LXR agonists for 48 h before Toll-like receptor (TLR) stimulation.

Total vulnerability of the littoral zone to climate change-driven natural hazards in north Brittany, France.

Current worldwide projections of sea-level rise show a staggering increase in water level of up to 2 m by 2100 owing to global warming exacerbated by anthropogenically induced climate change. While amplified rates of sea-level rise is an immense hazard to coastal communities, storm surges are expected to increase in intensity and frequency making it an equally significant threat to coastal populations. In France, these hazards are not uncommon with records of extreme tempests every thousand years in the Holocene.

Redescription of Castianeira zetes Simon, 1897 (Araneae, Corinnidae, Castianeirinae).

The corinnid species Castianeira zetes was described by Simon in 1897. It has been redescribed several times (Gravely 1931; Tikader 1981; Tikader Biswas 1981; Majumder Tikader 1991; Biswas Raychaudhuri 2000; Sen et al. 2015; Dhali et al.

A review of the wasp mimicking spider genus Coenoptychus Simon, 1885 (Araneae: Corinnidae: Castianeirinae).

The monotypic velvet ant-mimicking spider genus Coenoptychus Simon, 1885 is revised. The paper provides the first detailed morphological and genitalic description, with the first description and illustrations of the male of the type species, Coenoptychus pulcher Simon, 1885, and a redescription of its female. Two new combinations are proposed: Coenoptychus mutillicus (Haddad, 2004) comb.

On the genus Tylorida Simon, 1894 with the first record of the genus Simon, 1895 from India (Araneae: Tetragnathidae, Leucauginae).

The tetragnathid spider genus Tylorida Simon, 1894 is reviewed in India. The relationship of Tylorida with Orsinome Thorell, 1890 is discussed and illustrated. The taxonomic significance of male chelicerae of Tylorida spp.

The male of the orb-weaving spider Plebs mitratus (Simon, 1895) and a redescription of the female (Araneae, Araneidae).

The orb-weaving spider genus Plebs Joseph & Framenau, 2012 currently has only two representatives in India: Plebs himalayaensis (Tikader, 1975) from the Himalayas and Plebs mitratus (Simon, 1895) from the Nilgiris and Anamudi Shola National Park (World Spider Catalog 2016), both are found in high altitude mountainous habitats (Joseph & Framenau 2012). Both species were known only from females (World Spider Catalog 2016), although Sherriffs (1918, 1919) provided a description of an immature male of P. mitratus.

Paroxysmal sympathetic hyperactivity in severe traumatic brain injury.

Background: Paroxysmal sympathetic hyperactivity (PSH) is a less-known complication of traumatic brain injury (TBI). This study was done to assess the clinical features and outcome of patients who develop PSH following severe TBI.

Methods: A prospective observational study was done on patients, admitted in the intensive care unit, for treatment of severe TBI.

Cyrtarachne keralensis Jose, 2011 is a junior synonym of Anepsion maritatum (O. Pickard-Cambridge, 1877) (Araneae, Araneidae).

The Indo-pacific araneid genus Anepsion, with A. rhomboides (L. Koch, 1867) as the type species, was erected by Strand in 1929.

Paroxysmal sympathetic hyperactivity in pediatric traumatic brain injury: A case series of four patients.

Paroxysmal sympathetic hyperactivity (PSH) is a condition in which there is extreme autonomic dysregulation leading to multiple episodes of sympathetic hyperactivity. Its occurrence after traumatic brain injury (TBI) in pediatric population is a neglected scenario. In our series, all pediatric patients with moderate and severe head injuries were studied and those patients who developed PSH were monitored for the PSH episodes.

Castianeira furva sp. nov. (Araneae, Corinnidae, Castianeirinae), a new polymorphic ground sac spider from the southern Western Ghats of India.

The ground-dwelling, ant-mimicking corinnid spider genus Castianeira, with Castianeira rubicunda as type species, was erected by Keyserling (1879). Members of the genus are closely related to the Afrotropical genus Cambalida Simon, 1910 (Haddad 2012a) and are distributed mainly in tropical and temperate regions of the world except for Australia and nearby islands (World Spider Catalog 2015). The genus was revised from the Nearctic Region and south-east Asia (Reiskind 1969 and Deeleman-Reinhold 2001, respectively) and currently includes 126 described species, making it as the largest genus within the family Corinnidae (World Spider Catalog 2015).

An updated review of the genus Martensopoda Jäger, 2006 (Araneae: Sparassidae: Heteropodinae).

A new species of the huntsman spider genus Martensopoda Jäger, 2006, M. sanctor sp. nov.

Description of new species of Stenaelurillus Simon, 1886 from the Western Ghats of India with the redescription of Stenaelurilluslesserti Reimoser, 1934 and notes on mating plug in the genus (Arachnida, Araneae, Salticidae).

A new species of the jumping spider genus Stenaelurillus Simon, 1886, Stenaelurillusalbus sp. n., is described from the Western Ghats of India, one of the biodiversity hotspots of the world.

On the genus Hermippus Simon, 1893 (Araneae: Zodariidae, Zodariinae) in India with the description of three new species from the Western Ghats and proposing a new biogeographical hypothesis for the distribution of the genus.

Three new species of the ant-eating spider genus Hermippus Simon, 1893, H. globosus sp. nov.