Development and validation of 3D printed anthropomorphic head phantom with eccentric holes for medical LINAC quality assurance testing in stereotactic radiosurgery.

Stereotactic Radiosurgery (SRS) for brain tumors using Medical Linear Accelerator (LINAC) demands high precision and accuracy. A specific Quality Assurance (QA) is essential for every patient undergoing SRS to protect nearby non-cancerous cells by ensuring that the X-ray beams are targeted according to tumor position. In this work, a water-filled generic anthropomorphic head phantom consisting of two removable parts with eccentric holes was developed using Additive Manufacturing (AM) process for performing QA in SRS.

Design, fabrication, and characterization of a drift tube linac type double gap re-buncher cavity.

The Low Energy High Intensity Proton Accelerator (LEHIPA) at Bhabha Atomic Research Centre, India, has recently been commissioned to the target energy of 20 MeV by beam acceleration through a 352 MHz radio frequency quadrupole (RFQ) and drift tube linac (DTL). The medium energy beam transport (MEBT) line of LEHIPA matches the 3 MeV beam from RFQ to the DTL using four electromagnetic quadrupoles and a re-buncher cavity. In the beam transport lines of high frequency linacs, TM010 mode single gap buncher cavities are conventionally used, while a double gap re-buncher cavity was chosen for the short length LEHIPA MEBT based on beam dynamics simulations.

Tomato plant leaf disease segmentation and multiclass disease detection using hybrid optimization enabled deep learning.

Production of crops is increasing day by day in agriculture sectors. The insecurity of food is a main reason of plant disease and is a main global issue that humans face these days. With the design of contemporary environmental agriculture, more focus is devised for yielding the crop and elevating its quality.

Use of extracorporeal membrane oxygenation in massive amlodipine overdose.

Calcium-channel blocker overdose can result in profound vasoplegia and cardiogenic shock, which can quickly spiral into multi-organ failure and death. In this case report, we discuss two separate cases of massive amlodipine overdose with polydrug intoxication (Patient A: amlodipine and quetiapine; Patient B: amlodipine, fluoxetine and zopiclone), both of which were complicated by life-threatening vasoplegic shock refractory to supportive therapy (endotracheal intubation, fluid resuscitation, activated charcoal, vasopressors and inotropes), multimodal antidotes (calcium and hyper-insulinemic euglycemic therapy) and even second-line treatment (methylene blue and therapeutic plasma exchange). Despite exhausting all therapeutic options, resuscitation remained futile with no clinical response elicited until veno-arterial extracorporeal membrane oxygenation (ECMO) salvage therapy was initiated in both cases as a bridge-to-recovery.

Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic's Potentiation in Multi Drug Resistant .

Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the antibacterial potential of a graphene oxide nanosheet (GO), a graphene oxide-zinc oxide nanocomposite (GO/ZnO), a graphene oxide-chitosan nanocomposite (GO-CS), a zinc oxide decorated graphene oxide-chitosan nanocomposite (GO-CS/ZnO), and zinc oxide nanoparticles (ZnO) alone and in a blend with antibiotics against a PS-2 isolate of . These nanocomposites reduced the MIC of tetracycline (TET) from 16 folds to 64 folds against a multidrug-resistant clinical isolate.

A fully implantable wireless bidirectional neuromodulation system for mice.

Novel research in the field of bioelectronic medicine requires neuromodulation systems that pair high-performance neurostimulation and bio-signal acquisition hardware with advanced signal processing and control algorithms. Although mice are the most commonly used animal in medical research, the size, weight, and power requirements of such bioelectronic systems either preclude use in mice or impose significant constraints on experimental design. Here, a fully-implantable recording and stimulation neuromodulation system suitable for use in mice is presented, measuring 2.

Formulation and performance evaluation of polymeric mixed micelles encapsulated with baicalein for breast cancer treatment.

The present study is aimed to formulate baicalein-loaded mixed micelles to enhance the solubility and oral bioavailability. Baicalein encapsulated D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and pluronic F127 (F127) combined micelles were prepared and investigated for anticancer effect. The optimized formulation contains 25.

Nutrient concentrations and distribution of phytoplankton pigments in recently deposited sediments of a positive tropical estuary.

Investigation of nutrients in the water column and phytoplankton pigments in recently formed modern sediments (0-5 cm) was carried out in Cochin estuary. The anthropogenic impacts were assessed using nutrients, nitrate, and phosphate in combination with phytopigments in sediments. The nitrate and phosphate concentration during the study ranged from 0.

An improved strip-line fast Faraday cup for beam bunch measurements.

A 3 MeV proton radio frequency quadrupole (RFQ) accelerator has been designed, built, and commissioned at the Bhabha Atomic Research Centre, India. A compact wide bandwidth strip-line fast Faraday cup (SFFC) has been developed for the beam bunch measurements of the 352 MHz RFQ. The SFFC design is improvised over the standard strip-line FFC designs with a thicker strip, which can withstand larger beam intensities.

Geochemical fractionation of trace elements in the coral reef sediments of the Lakshadweep Archipelago, Indian Ocean.

Geochemical fractionation of seven trace elements (Cr, Mn, Fe, Cu, Zn, Cd, and Pb) was investigated in the surficial coral reef sediments of three inhabited islands (Kavaratti, Kadmat, and Agatti) belonging to the Lakshadweep Archipelago. The observations indicated that the metals showed their highest contents in the residual fraction of geological origin. The extent of risk, bioavailability, and contamination of trace elements was assessed by risk assessment codes and contamination factors.

Spatial and Temporal Variations of Arsenic Distribution in a Tropical Estuary Along the West Coast of India.

Arsenic (As) contamination was studied and reported for the first time in the sediments of the Cochin estuary. Surface sediment samples were collected from twenty-seven stations encompassing the entire estuary constituting south, central and north estuary. The total As concentration varied from 0.

Spatial variation of trace element concentration and contamination assessment in the coral reef sediments of Lakshadweep Archipelago, Indian Ocean.

Surface sediments were collected from the shore and lagoons of Kavaratti, Kadmat and Agatti islands of Lakshadweep Archipelago and analysed for trace element concentration. The sediment contamination was assessed on the basis of geochemical, biological hazard and ecological risk indices. Except Cd and Pb, all the other trace elements selected for the study were below the contamination level.

Institutional microbial analysis of odontogenic infections and their empirical antibiotic sensitivity.

Unlabelled: Most purulent orofacial infections are of odontogenic origin. It is well established that odontogenic infections are polymicrobial in nature. Empiric antibiotics were administered before the culture and sensitivity test results were obtained and specific antibiotics were administered based on the culture and sensitivity test results.

Sialocele: A rare sequlae of transparotid approach in subcondylar fracture management.

Iatrogenic injury and/or damage to the parotid salivary gland during transparotid approach for open reduction and internal fixation of mandibular condyle fracture is a rare event. Accumulation of saliva in the gland leads to formation of a sialocele. Huge sialocele often seeks drain through the most dependent area through an extraoral wound, whereas in the absence of extraoral fistula, saliva can be redirected intraorally using a stent.

Beam emittance measurements and simulations of injector line for radio frequency quadrupole.

A 400 keV deuteron (D(+)) radio frequency quadrupole (RFQ) accelerator has been designed, built, and commissioned at the Bhabha Atomic Research Centre, India. A beam line has been developed for injecting deuterons into the 400 keV RFQ. This comprises of a RF plasma ion source and a low energy beam transport (LEBT) system, consisting of two solenoid magnets and two steerer magnets.

Salvage of venous congestion using medicinal leeches for traumatic nasal flap.

Medicinal leeches are extremely useful and safe in the salvage of venous outflow compromised tissue, particularly in digit replants and various forms of flaps. Although it is unusual for a partial soft tissue avulsion of the face to require medicinal leech therapy, situations may occur in which there is adequate arterial inflow but inadequate venous outflow. In such cases, medicinal leeches may play a very important role in salvaging the soft tissue segment.

Genetic diversity and population structure analysis between Indian red jungle fowl and domestic chicken using microsatellite markers.

The present study was conducted to assess the genetic diversity, population structure, and relatedness in Indian red jungle fowl (RJF, Gallus gallus murgi) from northern India and three domestic chicken populations (gallus gallus domesticus), maintained at the institute farms, namely White Leghorn (WL), Aseel (AS) and Red Cornish (RC) using 25 microsatellite markers. All the markers were polymorphic, the number of alleles at each locus ranged from five (MCW0111) to forty-three (LEI0212) with an average number of 19 alleles per locus. Across all loci, the mean expected heterozygosity and polymorphic information content were 0.

Design, development, and acceleration trials of radio-frequency quadrupole.

A deuteron radio frequency quadrupole (RFQ) accelerator has been designed, fabricated, and tested at BARC, which will be used for neutron generation. The RFQ operates at a frequency of 350 MHz and needs an inter-vane voltage of 44 kV to accelerate the deuteron beam to 400 keV within a length of 1.03 m.

'Doing things differently'--working towards distributed responsibility within memory assessment services.

Objectives: To compare initial diagnostic hypotheses made by Allied Health Professionals (AHP) (mental health nurses, occupational therapists and social workers) with subsequent formal multidisciplinary formulation based upon the full possession of investigations, neuropsychological tests and brain imaging. Design Prospective analysis.

Design: Prospective analysis.

Compact electrostatic beam optics for multi-element focused ion beams: simulation and experiments.

Electrostatic beam optics for a multi-element focused ion beam (MEFIB) system comprising of a microwave multicusp plasma (ion) source is designed with the help of two widely known and commercially available beam simulation codes: AXCEL-INP and SIMION. The input parameters to the simulations are obtained from experiments carried out in the system. A single and a double Einzel lens system (ELS) with and without beam limiting apertures (S) have been investigated.

Analysis of aerosol emission and hazard evaluation of electrical discharge machining (EDM) process.

The safety and environmental aspects of a manufacturing process are important due to increased environmental regulations and life quality. In this paper, the concentration of aerosols in the breathing zone of the operator of Electrical Discharge Machining (EDM), a commonly used non traditional manufacturing process is presented. The pattern of aerosol emissions from this process with varying process parameters such as peak current, pulse duration, dielectric flushing pressure and the level of dielectric was evaluated.

Subcutoff microwave driven plasma ion sources for multielemental focused ion beam systems.

A compact microwave driven plasma ion source for focused ion beam applications has been developed. Several gas species have been experimented including argon, krypton, and hydrogen. The plasma, confined by a minimum B multicusp magnetic field, has good radial and axial uniformity.

Lattice strain and lattice expansion of nanoparticles of MgAl2O4 as a function of particle size.

Reduction in the physical dimension of a crystalline solid lead to regular changes in the lattice constants. The lattice expansion or contraction in nanoparticles depend on a number of factors like nature of atoms in the interior, surface atoms, surface surroundings, dangling bonds, and oxygen concentration on the surface. XRD patterns of nanoparticles of MgAl2O4 having average particle size 7 nm, 9 nm, and 19 nm show that lattice parameters undergo contraction or repulsion along different planes.