Heritability of the severity of diabetic retinopathy: the FIND-Eye study.

Purpose: Diabetic retinopathy (DR) and diabetic nephropathy (DN) are serious microvascular complications of diabetes mellitus. Correlations between severity of DR and DN and computed heritability estimates for DR were determined in a large, multiethnic sample of diabetic families. The hypothesis was that (1) the severity of DR correlates with the presence and severity of nephropathy in individuals with diabetes mellitus, and (2) the severity of DR is under significant familial influence in members of multiplex diabetic families.

Clinician versus reading center assessment of cytomegalovirus retinitis lesion size.

Purpose: To compare clinician and fundus photograph reading center assessments of the cytomegalovirus (CMV) retinitis area and change in the CMV retinitis area over time, and to investigate how these assessments correlate with the visual field (VF) of eyes with CMV retinitis.

Design: Analysis of pooled data from 2 multicenter randomized clinical trials and 1 prospective multicenter epidemiologic study.

Participants: Ninety-five eyes of 79 patients.