Diffuse idiopathic skeletal hyperostosis (DISH): Increased prevalence in Pacific Islanders.

Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) is a musculoskeletal disorder in which ligaments and entheses slowly become ossified, leading to decreased mobility and pain. The prevalence is variably reported as between 3% and 25% of the population over 50. In Australasia, the prevalence and severity of DISH has long been thought by radiologists to be high in certain populations, particularly among Pacific Islanders.

Diffusion and Perfusion MR Imaging in Acute Stroke: Clinical Utility and Potential Limitations for Treatment Selection.

Magnetic resonance (MR) diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) offer unique insight into acute ischemic stroke pathophysiology. These techniques may offer the ability to apply pathophysiology to accurately individualize acute stroke reperfusion treatment, including extending the opportunity of reperfusion treatment to well beyond the current time-based treatment windows.This review examines the use of DWI and PWI in the major stroke trials, their current clinical utility, and potential limitations for reperfusion treatment selection.

Expression of the zebrafish Staufen gene in the embryo and adult.

Staufen, a double stranded RNA binding protein, has been shown to be involved in creating and maintaining cellular asymmetry in the Drosophila oocyte, neuroblast, and mammalian neuron. Staufen binds to the 3' UTR of specific mRNAs and acts in their localization and anchoring to various subcellular domains. Staufen's molecular interactions during development have been limited to investigations in Drosophila melanogaster.

IGF-I and IGFBP-3 transport in the rat heart.

Specific binding of IGF-binding protein (IGFBP)-3 was shown to be present in the isolated, beating rat heart. The uptake of perfused (125)I-labeled IGF-I in the beating heart was decreased to 9% by blocking IGF-I binding sites with the IGF-I analog Long R(3) (LR(3)) IGF-I. When LR(3) was perfused with complexes of (125)I-IGF-I.