Publications by authors named "Matheus William Bandeira Oliveira"
Chemicals such as triclosan are a concern because of their presence on daily products (soap, deodorant, hand sanitizers …), consequently this compound has an ubiquitous presence in the environment. Little is known about the effect of this bactericide on aquatic life. The aim of this study is to analyze triclosan exposure (24 h) to an in vitro model, zebrafish hepatocytes cell line (ZF-L), if it can be cytotoxic (mitochondrial activity, membrane stability and apoptosis) and if can activate ATP-binding cassette (ABC) proteins (activity, expression and protein/compound affinity).
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- The study aimed to investigate the calcium channel affinity and effects of 43 new lipophilic dihydropyridines, focusing on their antihypertensive and antioxidant properties, alongside toxicity testing compared to nifedipine.
- Animals with induced hypertension were treated for 56 days, first with N (ω) -nitro-L-arginine methyl ester and then with the dihydropyridines or nifedipine, with measurements taken for blood pressure, heart rate, and oxidative stress markers.
- The findings showed that two new dihydropyridines (2c and 9a) effectively lowered blood pressure and heart rate to normal levels, exhibiting superior antioxidant properties compared to nifedipine, indicating their