Publications by authors named "Matheus Palazzo"
High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID-19 patients: HMGB1 as a biomarker of worst prognosis.
Amanda Roberta Revoredo Vicentino Vanderlei da Silva Fraga-Junior Matheus Palazzo Natalia Recardo Amorim Tasmo Danielle A S Rodrigues
Clin Transl Sci
April 2023
Article Synopsis
- Researchers studied COVID-19 patients in Brazil to identify molecular biomarkers linked to disease severity, focusing on inflammatory mediators in patients compared to healthy controls.
- They found that critically ill patients showed elevated serum levels of multiple inflammatory mediators, including HMGB1, which is associated with worse outcomes.
- The study suggests that high levels of HMGB1 (over 125.4 ng/ml) could serve as a useful biomarker for predicting severe cases and increased risk of death in COVID-19 patients.