Cardiovascular prevention in clinical practice (ESC and German guidelines 2007).

Preventive efforts should be guided by the patient's global cardiovascular (CV) risk. A risk stratification should be done in every person > age 35 with more than a single risk factor. Recommendations for improved lifestyle are applicable to all persons with CV risk factors: smoking cessation, daily exercise, normal body mass index, Mediterranean diet, blood pressure < 140 mmHg systolic, and LDL cholesterol < 130 mg/dl are beneficial.

Agreement among response to intervention criteria for identifying responder status.

In order to better understand the extent to which operationalizations of response to intervention (RTI) overlap and agree in identifying adequate and inadequate responders, an existing database of 399 first grade students was evaluated in relation to cut-points, measures, and methods frequently cited for the identification of inadequate responders to instruction. A series of 543 2x2 measures of association (808 total comparisons) were computed to address the agreement of different operationalizations of RTI. The results indicate that agreement is generally poor and that different methods tend to identify different students as inadequate responders, although agreement for identifying adequate responders is higher.

Teaching struggling readers who are native Spanish speakers: what do we know?

Purpose: The purpose of this article is to share what we have learned from a series of 4 scientific studies about preventing reading failure through early intervention with native Spanish-speaking students who are struggling readers. The goal is to provide guidance to practitioners about effective practices for working with native Spanish-speaking children who are struggling to become readers using evidence rather than conjecture and opinion.

Method: First, the method and findings are summarized from each of 4 scientific studies (2 English, 2 Spanish) examining supplemental reading intervention that was provided in addition to core reading instruction in first grade.

Effectiveness of Spanish intervention for first-grade English language learners at risk for reading difficulties.

The effectiveness of an explicit, systematic reading intervention for first-grade students whose home language was Spanish and who were at risk for reading difficulties was examined. Participants were 69 students in 20 classrooms in 7 schools from 3 districts who initially did not pass the screening in Spanish and were randomly assigned within schools to a treatment or comparison group; after 7 months, 64 students remained in the study. The intervention matched the language of instruction of their core reading program (Spanish).

[Value of coronary artery calcium measurements in primary prevention].

Frequently, myocardial infarction or sudden coronary death are the index manifestations of coronary artery disease. In view of the high out-of-hospital mortality of acute myocardial infarction, medical care is unable to provide a benefit for many patients. Against this background, it is an important aim of measuring coronary calcium to identify asymptomatic subjects with an increased coronary risk who are likely to derive a benefit from risk-modifying therapy.

[The role of lipid metabolism in the prevention of coronary heart disease].

Prevention of cardiovascular disease should be considered as a continuum from low to high risk: those at the highest risk are patients with clinically manifest cardiovascular disease, followed by subjects without known cardiovascular disease at different levels of risk from high to low. Today there is clear evidence that an independent relationship exists between plasma LDL cholesterol levels and the risk for coronary heart disease. The relationship between other plasma lipoproteins and atherosclerosis is more complex.

Do students with and without lexical retrieval weaknesses respond differently to instruction?

Deficits in phonological processing are theorized to be responsible for at least some reading disabilities. A considerable amount of research demonstrates that many students can be taught one of these phonological processes-phonemic awareness. However, not all students have responded favorably to this instruction.

[Cholesterol: blood levels or total risk as a guide to preventive treatment?].

The results of a cholesterol lowering therapy with statins do belong to the best documented steps in medical treatment. The newer studies like HPS and LIPID have shown a therapeutic benefit across all serum-cholesterol levels, nearly obviating the need for a prior determination of the cholesterol values. Why not using the serum-cholesterol level as the only guide to therapy? Since there is no threshold indicating the need for treatment, there is the danger of an unlimited inflation of the indications for therapy, possibly leading to a collapse of the health care system.

The prevention and identification of reading disability.

There is abundant evidence that intervention for the prevention of reading disability is effective in dramatically reducing the prevalence of reading disability. This article explores the current state of knowledge regarding the causation and prevalence of reading disability, along with evidence that the incidence of this condition can be dramatically reduced through quality intervention. Specifically, we (1) explore what is known about the nature and causes of reading disability, (2) examine how reading disability can best be identified, and (3) estimate the percentage of children that have severe reading difficulties that indicate the true presence of a disability.

Brain activation profiles during the early stages of reading acquisition.

In the present study, we demonstrate for the first time the presence of an aberrant brain mechanism for reading in children who have just started acquiring reading skills. Children who, at the end of kindergarten, are found to be at risk for developing reading problems display markedly different activation profiles than children who have, at this stage, already mastered important prereading skills. This aberrant profile is characterized by the lack of engagement of the left-hemisphere superior temporal region, an area normally involved in converting print into sound, and an increase in activation in the corresponding right-hemisphere region.

[Lipid intervention and coronary heart disease in men less than 56 years of age. The Coronary Intervention Study: CIS].

Unlabelled: The CIS was undertaken with the aim to evaluate the effects of lipid modifications on angiographic progression and regression of CAD in patients with CAD and hypercholesterolemia. The design included a multicenter randomized, double-blind, parallel, placebo-controlled comparison, with target and safety limits for adjusting the trial medication depending on the LDL cholesterol level (LDL-C) achieved, i.e.

[Partial inpatient cardiologic rehabilitation in an urban satellite center of a rehabilitation clinic: the Munich model].

In April 1996 the Munich Rehabilitation Center was founded by the Social Security Agency as a "satellite center" of the "Klinik Höhenried for Cardiovascular Diseases", which is located 50 km south of Munich near the lake Starnberg and performs in-patient rehabilitation since 1967. The Munich Rehabilitation Center is exclusively designated for outpatient rehabilitation for patients in the Munich area. Monday to Friday from 9 a.

Preparing students with special needs for reintegration: curriculum-based measurement's impact on transenvironmental programming.

The original intent of special education pull-out services was to remove students from general education temporarily for intensive, individualized instruction in deficit areas. In many school districts, however, it seems that once students participate in pull-out services, there is little effort to return them to general education. One explanation for this is that not much is known about how best to prepare students for movement up the cascade of services, including reintegration into the mainstream.

Plasma total homocysteine levels in patients with early-onset coronary heart disease and a low cardiovascular risk profile.

Mild hyperhomocysteinemia has been associated with an increased risk to develop premature coronary heart disease. Recently, the homocysteine concentration has been positively correlated with several main cardiovascular risk factors. We addressed the issue as to whether patients with coronary heart disease and a low cardiovascular risk profile also have a higher prevalence of hyperhomocysteinemia than matched controls.

The effect of simvastatin on progression of coronary artery disease. The Multicenter coronary Intervention Study (CIS).

Background: In several angiographic trials, HMG-CoA reductase inhibitors have shown a beneficial effect on the progression of coronary artery disease. Using 20 mg simvastatin, day-1, a treatment period of up to 4 years was necessary to show a significant reduction in coronary artery disease progression. The question remains however whether higher dosages of simvastatin would be more advantageous in respect to the magnitude of the effect and the required time interval to demonstrate treatment efficacy.

Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group.

1. Trimetazidine has a direct anti-ischaemic effect on the myocardium without altering the rate x pressure product or coronary blood flow. 2.