The Potential of Congo Red Supplied Aggregates of Multitargeted Tyrosine Kinase Inhibitor (Sorafenib, BAY-43-9006) in Enhancing Therapeutic Impact on Bladder Cancer.

Bladder cancer is a common malignancy associated with high recurrence rates and potential progression to invasive forms. Sorafenib, a multi-targeted tyrosine kinase inhibitor, has shown promise in anti-cancer therapy, but its cytotoxicity to normal cells and aggregation in solution limits its clinical application. To address these challenges, we investigated the formation of supramolecular aggregates of sorafenib with Congo red (CR), a bis-azo dye known for its supramolecular interaction.

Application of the arm-cranking 30-second Wingate Anaerobic Test (the WAnT) to assess power in amputee football players.

Purpose: The aim of this work was to determine anaerobic performance in male amputee football players considering types and levels of limb impairment, playing position, anthropometric parameters, and comparing the findings to reference values. Relationship between parameters in the laboratory anaerobic test and the handgrip test was checked.

Methods: The 30-second Wingate Anaerobic Test (peak power, mean power, relative peak power, relative mean power, time to achieve peak power, fatigue index) on the arm-crank ergometer (LODE ANGIO), the FUTREX 6100 (Futrex, Gaithersburg, USA) and the handgrip test were used in amputee football players (n = 23).