Publications by authors named "Mateusz Spiewak"

Background: Sudden cardiac arrest (SCA) risk stratification in patients with mitral valve prolapse (MVP) may be complicated by other potential causes of arrhythmia.

Objectives: We aimed to characterize SCA survivors with isolated (iMVP) and non-isolated MVP (non-iMVP) and to assess their long-term follow-up.

Methods: This ambispective study included 75 patients with MVP who experienced SCA and were treated in our center between 2009-2024.

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Background: It remains a challenge to determine the best time to refer asymptomatic patients for aortic valve replacement (AVR).

Aims: We aimed to determine whether late gadolinium enhancement (LGE) in patients with asymptomatic aortic stenosis (AS) has an independent prognostic significance for adverse postoperative cardiovascular events and changes in left ventricular (LV) hypertrophy (LVH) and LV ejection fraction (LVEF).

Methods: Consecutive patients with severe asymptomatic AS were prospectively enrolled in the study.

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Article Synopsis
  • Malignant hypertension (MHT) is a severe increase in blood pressure that causes rapid damage to vital organs like the brain, heart, and kidneys, requiring urgent treatment to reduce BP to prevent further complications.
  • The main cause of MHT is often patients not following their prescribed antihypertensive medication, but certain therapies like antiangiogenic and immunosuppressants can also trigger this condition.
  • Despite improvements in treatment leading to better prognoses, patients with MHT remain at a high risk for serious heart and kidney problems, prompting the need for more research and improved management strategies.
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The aim of this study was to assess the impact of cardiac magnetic resonance (CMR) on the diagnosis in patients with known or suspected left ventricular noncompaction (LVNC). We retrospectively reviewed the medical charts of 12,811 consecutive patients who had CMR studies between 2008 and 2022 in a large tertiary center. We included patients referred for CMR because of known or suspected LVNC.

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The year 2023 marks 60 years since the first pacemaker was implanted in Poland. The number of implantable cardiac electrotherapy devices (CIEDs), including pacemakers, cardioverter-defibrillators, and resynchronization therapy systems, has been systematically increasing in the subsequent decades. It is estimated that nearly 500,000 Poles have an implanted cardiac electrotherapy device, making optimal diagnostic imaging with the use of magnetic resonance imaging (MRI) a clinically and epidemiologically important issue.

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Aortic stenosis is the most common form of valve disease in the Western world and a major healthcare burden. Although echocardiography remains the central modality for the diagnosis and assessment of aortic stenosis, recently, advanced cardiac imaging with cardiovascular magnetic resonance, computed tomography, and positron emission tomography have provided invaluable pathological insights that may guide the personalized management of the disease. In this review, we discuss applications of these novel non-invasive imaging modalities for establishing the diagnosis, monitoring disease progression, and eventually planning the invasive treatment of aortic stenosis.

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Background: COVID-19 is a great medical challenge as it provokes acute respiratory distress and has pulmonary manifestations and cardiovascular (CV) consequences.

Aims: This study compared cardiac injury in COVID-19 myocarditis patients with non-COVID-19 myocarditis patients.

Methods: Patients who recovered from COVID-19 were scheduled for cardiovascular magnetic resonance (CMR) owing to clinical myocarditis suspicion.

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Several forms of secondary hypertension carry a high risk of cardiac morbidity and mortality. Evaluation of cardiac phenotypes in secondary hypertension provides a unique opportunity to study underlying hormonal and biochemical mechanisms affecting the heart. We review the characteristics of cardiac dysfunction in different forms of secondary hypertension and clarify the mechanisms behind the higher prevalence of heart damage in these patients than in those with primary hypertension.

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Isolated myocardial edema not accompanied by late gadolinium enhancement (LGE) may be occasionally found on cardiac magnetic resonance (CMR). This type of picture may be encountered in patients with suspected myocarditis, post some acute cardiac events, with cardiac allograft rejection or even in athletes after an extreme exercise. Currently, there is no clear management strategy for this type of incidental finding.

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Article Synopsis
  • A 36-year-old man with a history of dysarthria and cardiac arrhythmia since childhood developed severe cerebellar-extrapyramidal symptoms and heart failure due to dilated cardiomyopathy of unspecified origin.
  • Brain MRI revealed significant cerebellar atrophy, and upon cardiac transplantation, genetic testing identified biallelic variants, including known and novel mutations.
  • Further analysis showed reduced TPP1 activity and specific findings in heart tissue biopsies, suggesting symptoms aligned with benign forms of ceroid lipofuscinosis type 2 and features of autosomal recessive spinocerebellar ataxia type 7.
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Background: The heart failure (HF) population is estimated to be 64.3 million people worldwide and continues to grow. Identifying the underlying cause of HF is crucial for patient management and prognosis.

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Background: Peripartum (PPCM) and dilated (DCM) cardiomyopathies are distinct forms of cardiac disease that share certain aspects in clinical presentation.

Aim: We hypothesized that different cardiac structural changes underlie PPCM and DCM, and we aimed to investigate them with cardiovascular magnetic resonance (CMR).

Methods: We included 21 PPCM patients (30.

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Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are chosen. Although cardiac magnetic resonance imaging (MRI) is considered the reference standard for assessing the regurgitant volume (RV) and fraction (RF), echocardiography is the most common method for assessing MR severity. Accordingly, the aim of this study was to compare the results of echocardiography and cardiac MRI for assessing MR severity in a cohort of patients with HCM.

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Article Synopsis
  • The DETECTIN-HF study developed a clinical risk calculator to better assess the risk of sustained ventricular arrhythmias and sudden cardiac death in patients with non-ischemic dilated cardiomyopathy (DCM), beyond relying solely on left-ventricular ejection fraction.
  • The study included 1,393 patients and identified seven key clinical parameters that help predict life-threatening cardiac events, showing a calibration slope of 0.97 and a C-index of 0.72.
  • The new risk model can potentially decrease unnecessary implantable cardioverter-defibrillator (ICD) implants by 15% while still effectively protecting patients at significant risk (5-year risk ≥8.5%).
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In hypertrophic cardiomyopathy (HCM) patients, left ventricular (LV) maximal wall thickness (MWT) is one of the most important factors determining sudden cardiac death (SCD) risk. In a large unselected sample of HCM patients, we aimed to simulate what changes would occur in the calculated SCD risk according to the European HCM Risk-SCD calculator when MWT measured using echocardiography was changed to MWT measured using MRI. All consecutive patients with HCM who underwent cardiac MRI were included.

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