Diauxic Growth at the Mesoscopic Scale.

In the present paper, we study a diauxic growth that can be generated by a class of model at the mesoscopic scale. Although the diauxic growth can be related to the macroscopic scale, similarly to the logistic scale, one may ask whether models on mesoscopic or microscopic scales may lead to such a behavior. The present paper is the first step towards the developing of the mesoscopic models that lead to a diauxic growth at the macroscopic scale.

Mathematical Model Explaining the Role of CDC6 in the Diauxic Growth of CDK1 Activity during the M-Phase of the Cell Cycle.

In this paper we propose a role for the CDC 6 protein in the entry of cells into mitosis. This has not been considered in the literature so far. Recent experiments suggest that CDC 6 , upon entry into mitosis, inhibits the appearance of active CDK 1 and cyclin B complexes.

Flexibility vs. robustness in cell cycle regulation of timing of M-phase entry in Xenopus laevis embryo cell-free extract.

During the cell cycle, cyclin dependent kinase 1 (CDK1) and protein phosphatase 2A (PP2A) play major roles in the regulation of mitosis. CDK1 phosphorylates a series of substrates triggering M-phase entry. Most of these substrates are dephosphorylated by PP2A.