Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history.

One of the most crucial determinants of early-life development is the experience of childhood adversities. However, limited evidence is available for how these experiences shape later-life reproductive outcomes in women. Here we test the association between early-life adversities and reproductive parameters in women.

Risk and benefit for umbrella trials in oncology: a systematic review and meta-analysis.

Background: Umbrella clinical trials in precision oncology are designed to tailor therapies to the specific genetic changes within a tumor. Little is known about the risk/benefit ratio for umbrella clinical trials. The aim of our systematic review with meta-analysis was to evaluate the efficacy and safety profiles in cancer umbrella trials testing targeted drugs or a combination of targeted therapy with chemotherapy.

How relevant for you is to be a moral person? Polish validation of the Self-Importance of Moral Identity Scale.

Objective: The Self-Importance of Moral Identity Scale (SMIS) was developed by Aquino and Reeds with the purpose of measuring how people evaluate their private (Internalization subscale) and public (Symbolization subscale) moral identity. SMIS has become commonly and broadly used in many studies. The aim of this paper is to validate the Polish version of SMIS by analyzing its structure and relation to similar measures (such as The Moral Self-Concept Scale developed by Stake and The Moral Self-Image Scale created by Jordan, Leliveld and Tenbrunsel), declared past prosocial behaviors and readiness to donate money.

Dysregulated by stigma: Cortisol responses to repeated psychosocial stress in gay and heterosexual men.

Background: Research on pathways linking stigma with health inequalities affecting sexual minority populations, focused predominantly on exploring the hypothalamic-pituitary-adrenocortical (HPA) dysregulation profiles associated with chronic stress. One of such profiles reflecting a state of increased susceptibility to disease, and not yet studied among sexual minority individuals, is impaired habituation to repeated stress of the same type. In this study we explored whether sexual identity modulates endocrine stress responses and stress responses habituation in healthy heterosexual and gay men.

Risk and Benefit for Targeted Therapy Agents in Pediatric Phase II Trials in Oncology: A Systematic Review with a Meta-Analysis.

Background: For research with human participants to be ethical, risk must be in a favorable balance with potential benefits. Little is known about the risk/benefit ratio for pediatric cancer phase II trials testing targeted therapies.

Objective: Our aim was to conduct a systematic review of preliminary efficacy and safety profiles of phase II targeted therapy clinical trials in pediatric oncology.

Sexual Health Studies in Gay and Lesbian People: A Critical Review of the Literature.

Background: The subject of gay and lesbian sexual health seems to be highly understudied, at least partially due to general limitations inherent in the studies of sexuality as well as heteronormative bias and difficulties in reaching out to these populations.

Aim: To critically review the studies on gay and lesbian sexual health in order to identify the existing gaps and biases in the scope and general construction of the published research.

Methods: The dataset comprised 556 peer-reviewed articles identified through Medline search.

Inflammaging: Blame the sons. Relationships between the number of sons and the level of inflammatory mediators among post-reproductive women.

Objectives: Reproduction is costly, but sons and daughters differently influence maternal physiology, also in older age. In particular, having sons may negatively influence maternal health and may be associated with a shorter life span of mothers. Sons may also contribute to increased inflammaging, a chronic sub-clinical systemic inflammatory state characterized by elevated levels of serum inflammatory mediators.

The Relationship Between Spirituality, Health-Related Behavior, and Psychological Well-Being.

Studies suggest a positive association of spirituality and health behaviors with well-being (especially subjective well-being), but still the precise character of such relationships between all these constructs remains unknown. The present study aims to explore the relations between spirituality, health-related behaviors, and psychological well-being in the context of acquired education. A questionnaire survey was conducted among 595 students from six different universities, whose study programs either focused on the human body or the human mind and spirit.

Physical Activity, Sedentary Behavior, and Quality of Life among University Students.

The aim of our study was to explore the relation between physical activity, sedentary behavior, and the subjective and objective indicators of quality of life as well as life satisfaction among university students, whose education is related to different dimensions on health. Participants ( = 595) were invited to fill in a set of suitable questionnaires. The path analysis and linear regression were used to establish a relationship between the examined constructs.

Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus.

Introduction: Peripheral arterial occlusive disease (PAOD) is a disease with worldwide increasing occurrence. Diabetic patients are greatly exposed on the risk of PAOD and its complications. The aim of the study was to check the influence of preoperative HbA1C on the outcomes of patients with diabetes undergoing PAOD related endovascular treatment.

Occupational burnout and its overlapping effect with depression and anxiety.

Objectives: The problem of defining burnout concerns its overlapping effect with other syndromes and disorders, such as depression and anxiety. Additionally, some individual characteristics influence susceptibility to burnout (e.g.