Publications by Mateusz A Drozdz

Publications by authors named "Mateusz A Drozdz"

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A Phosphorylated Intermediate in the Activation of WNK Kinases.

Radha Akella Mateusz A Drozdz John M Humphreys Jenny Jiou Mateusz Z Durbacz

Biochemistry

May 2020

WNK kinases autoactivate by autophosphorylation. Crystallography of the kinase domain of WNK1 phosphorylated on the primary activating site (pWNK1) in the presence of AMP-PNP reveals a well-ordered but inactive configuration. This new pWNK1 structure features specific and unique interactions of the phosphoserine, less hydration, and smaller cavities compared with those of unphosphorylated WNK1 (uWNK1).

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