Randomized controlled trial of chlorhexidine gluconate, intranasal mupirocin, rifampin, and doxycycline versus chlorhexidine gluconate and intranasal mupirocin alone for the eradication of methicillin-resistant (MRSA) colonization.

Background: Several decolonization regimens have been studied to prevent recurrent methicillin-resistant (MRSA) infections. Clinical equipoise remains with regard to the role of MRSA decolonization. We compared initial MRSA clearance and subsequent MRSA recolonization rates over a 12-month period after standard decolonization (using topical chlorhexidine gluconate, and intranasal mupirocin) or systemic decolonization (using topical chlorhexidine gluconate, intranasal mupirocin, oral rifampin, and oral doxycycline).

Jamestown Canyon and snowshoe hare virus seroprevalence in New Brunswick.

Background: Jamestown Canyon virus (JCV) and snowshoe hare virus (SSHV) are wide-ranging mosquito-borne arboviruses in the California serogroup viruses (CSGV) that are known to circulate in New Brunswick. Despite potential for debilitating central nervous system manifestations, the prevalence of human exposure to these viruses in New Brunswick is unknown. The goal of this study was to quantify rates of human exposure in New Brunswick to these neglected arboviruses.

An Evaluation of Hepatitis C Screening in Infants and Children Born to Seropositive Mothers in Saint John, New Brunswick.

Background: The primary route of hepatitis C virus (HCV) infection in children is vertical transmission, from mother to fetus in utero. There is a lack of data on the prevalence of pediatric HCV acquired through vertical transmission in Saint John, New Brunswick. Furthermore, what risk factors may be associated with an increased likelihood for a child born to an HCV-seropositive mother should be known to direct screening practices.

Epidemiology, Microbiology, and Clinical Outcomes Among Patients With Intravenous Drug Use-Associated Infective Endocarditis in New Brunswick.

Background: Within the context of Canada's opioid crisis, medical complications associated with intravenous drug use (IVDU) are increasing. Infective endocarditis (IE) is a serious complication of IVDU, and understanding the characteristics of these patients could aid health systems, clinicians, and patients in the optimization of treatment and prevention of IVDU-IE.

Methods: At a tertiary care hospital in southern New Brunswick, we conducted a retrospective chart review to identify patients with IVDU-IE admitted between January 1, 2013, and December 31, 2017.

Differences among hepatitis C patients seen in community and specialist outpatient care settings.

Background: In the province of New Brunswick, care for patients infected with hepatitis C is provided in both community-based care settings and specialist-based care settings, but little is known about the differences between these populations. The aim of the current study is to characterize the demographic, socioeconomic, mental health and substance use factors of patients seen in these settings.

Methods: Enrolling sites for this study included four specialist office-based clinics and one community-based clinic in three communities in New Brunswick.

Early Successes in an Open Access, Provincially Funded Hepatitis C Treatment Program in Prince Edward Island.

Introduction: The availability of curative hepatitis C therapies has created an opportunity to improve treatment delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation.

Early Successes in an Open Access, Provincially Funded Hepatitis C Treatment Program in Prince Edward Island.

Introduction: The availability of curative hepatitis C therapies has created an opportunity to improve delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation.

Reentrant miscibility in two-dimensional symmetrical mixtures.

The Monte Carlo simulation method in the grand canonical ensemble is used to study the phase behavior of two-dimensional symmetrical binary mixtures of Lennard-Jones particles with negative nonadditivity and the weaker interaction between the pairs of unlike than between the pairs of like particles. We have determined the evolution of the phase diagram topology when the parameters describing the interaction between unlike particles vary. It has been found that such systems may exhibit reentrant miscibility in the liquid and the solid phases.

Symmetrical mixtures in external fields.

We have studied the behavior of symmetrical binary mixtures of Lennard-Jones particles in contact with strongly adsorbing walls using Monte Carlo simulation methods in the grand canonical and semi-grand canonical ensembles. Two types of the surface potential have been applied. The first depends on the distance from the surface only, while the second involves periodic modulations in the directions parallel to the wall.

The phase behavior of two-dimensional symmetrical mixtures in a weak external field of square symmetry.

Using Monte Carlo simulation methods in the grand canonical and semigrand canonical ensembles, we study the phase behavior of two-dimensional symmetrical binary mixtures of Lennard-Jones particles subjected to a weakly corrugated external field of a square symmetry. It is shown that the both vapor-liquid condensation and demixing transition in the liquid phase are not appreciably affected by a weakly corrugated external field. On the other hand, even a weakly corrugated external field considerably influences the structure of solid phases and the liquid-solid transition.

The phase behavior of two-dimensional symmetrical mixtures.

Using Monte Carlo simulation methods in the grand canonical and semigrand canonical ensembles, we study the phase behavior of two-dimensional symmetrical binary mixtures of Lennard-Jones particles. We discuss the interplay between the demixing transition in a liquid and the freezing in detail. Phase diagrams for several systems characterized by different parameters describing interactions in the system are presented.