The full range of ophthalmological clinical manifestations in systemic lupus erythematosus.

Purpose: To determine the full range of ophthalmological clinical manifestations in systemic lupus erythematosus (SLE) and to compare the systemic features associated with them.

Methods: Files of 13 patients with ocular SLE ( 20 eyes) diagnosed as per the American College of Rheumatology (ACR) 2012 revised criteria were retrospectively reviewed.

Results: The following clinical manifestations were found: keratoconjunctivitis sicca ( three patients), anterior uveitis associated with an inflammatory pseudo-tumor orbital mass ( one patient, one eye), episcleritis and periorbital edema ( one patient, two eyes), posterior scleritis ( one patient, two eyes), bilateral papillary edema in the context of idiopathic intracranial hypertension ( one patient, one eye), inflammatory optic neuritis ( one patient, one eye), and lupus retinopathies with varying degrees of capillary occlusions mainly arteriolar ( seven patients, 13 eyes) and larger arteries or veins (retinal arteries occlusions and retinal veins occlusions) ( one patient, two eyes).

Comparative Effectiveness of Intravitreal Anti-Vascular Endothelial Growth Factor Therapies for Managing Neovascular Age-Related Macular Degeneration: A Meta-Analysis.

Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) have become the standard of care for age-related macular degeneration (AMD). Although most pivotal trials have used monthly injections, alternative strategies that enable the injections to be administered on a more flexible schedule, including pro re nata (PRN) and treat-and-extend (T&E) regimens, are being applied more frequently. This review sought to provide further scientific evidence about the visual outcomes and treatment burden among the currently available anti-VEGF agents and regimens, including aflibercept, ranibizumab, abicipar and brolucizumab.

Geographic Atrophy and OCT Angiography: Descriptive Study and Correlation With Autofluorescence.

Background And Objective: Geographic atrophy (GA) involves the progressive loss of retinal pigment epithelium (RPE), photoreceptors, and choriocapillaris (CC). CC flow within a GA area is severely impaired in patients with atrophic age-related macular degeneration. The aim of this study was to compare GA area measured on optical coherence tomography angiography (OCTA) (CC nonperfusion area) and on fundus autofluorescence (FAF).

Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab.

Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) predictive morphological features for the outcome of Ranibizumab therapy for neovascular age-related macular degeneration (AMD).

Methods: This is a retrospective multicentric study that involved 64 eyes with naïve AMD. Patients who received three monthly intravitreal injections of Ranibizumab were stratified into (1) "responders" [≥ 5 letters gain on Early Treatment Diabetic Retinopathy Study (ETDRS) scale] and (2) "nonresponders" (< 5 letters gain).

Occupational cataracts and lens opacities in interventional cardiology (O'CLOC study): are X-Rays involved? Radiation-induced cataracts and lens opacities.

Background: The eye is well known to be sensitive to clearly high doses (>2 Gy) of ionizing radiation. In recent years, however, cataracts have been observed in populations exposed to lower doses. Interventional cardiologists are repeatedly and acutely exposed to scattered ionizing radiation (X-rays) during the diagnostic and therapeutic procedures they perform.

Interobserver and intraobserver reliability of detecting age-related macular degeneration using a nonmydriatic digital camera.

Purpose: To evaluate the interobserver and intraobserver reliability of detecting early and late age-related macular degeneration (AMD) using a nonmydriatic digital camera in two distinct groups of older people.

Design: Prospective study.

Methods: The two groups consisted of a series of patients older than 70 years hospitalized in a geriatric unit and a younger series of people older than 55 years.

Bilateral necrotizing scleritis following strabismus surgery for thyroid ophthalmopathy.

A case of a bilateral necrotizing scleritis following strabismus surgery for thyroid ophthalmopathy is described. A 71-year-old man was operated on for esotropia due to prior and equilibrated Grave's disease. Two weeks after surgery, he had a scleral necrosis that was located on the surgery sites (insertion of the two medial rectus muscles).

[Churg-Strauss syndrome and pulmonary fibrosis: an unusual association].

Introduction: Churg-Strauss syndrome (CSS) is characterized by asthma, hypereosinophilia, and vasculitis involving at least two extrapulmonary organs.

Case: We report a case of a patient with antineutrophilic cytoplasmic antibody-negative CSS who developed pulmonary interstitial fibrosis (PIF).

Discussion: The possible relations between CSS and PIF are discussed.