Publications by authors named "Matan Vidavski"
Article Synopsis
- This study focuses on how DNA-binding domains in transcription factors recognize specific sequence motifs in genomes, but in reality, they only bind to a small fraction of these motifs due to interactions with other transcription factors.
- The researchers developed a new method to test TF binding in yeast cells, allowing them to analyze thousands of designed sequences and measure how various transcription factors interacted with clusters of these motifs.
- The findings suggest that most TF binding can be explained by their independent interactions with individual motifs rather than by cooperative interactions between them, challenging previous ideas about how these factors work together in the genome.
DNA packaging within chromatin depends on histone chaperones and remodelers that form and position nucleosomes. Cells express multiple such chromatin regulators with overlapping in-vitro activities. Defining specific in-vivo activities requires monitoring histone dynamics during regulator depletion, which has been technically challenging.
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