Publications by authors named "Masuzyo Zyambo"
Article Synopsis
- Malnutrition is a major cause of child deaths globally, with Severe Acute Malnutrition (SAM) leading to high mortality rates, especially when compounded by infections or medical complications.
- A clinical trial conducted in Zambia and Zimbabwe evaluated four potential treatments for malnutrition-related enteropathy in 125 hospitalized children aged 6-59 months with SAM, comparing bovine colostrum, N-acetyl glucosamine, teduglutide, budesonide, and standard care over 14 days.
- Results indicated that teduglutide significantly reduced mucosal damage biomarkers, suggesting it may be a beneficial treatment for enteropathy in children with complicated malnutrition, with all interventions deemed safe.
Background: Environmental enteropathy is an example of a poorly-understood intestinal disorder affecting millions of children worldwide, characterized by malabsorption and stunting. Although there is increasing interest in non-invasive means of assessing intestinal structure and function, the potential value of intestinal biopsy for histology, immunostaining, RNA sequencing and epigenetic work means that endoscopic biopsy remains extremely valuable. We here report our experience in the BEECH (Biomarkers of Environmental Enteropathy in CHildren) study of stunting in Zambia, in the belief that it may help address the knowledge gap regarding the safety of endoscopic biopsy in vulnerable young children.
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